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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Keratin, type I cytoskeletal 17

SKU : BHE13805647

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1822m
Alternative Names	Cytokeratin-17 ; CK-17 ; Keratin-17 ; K17 ; Krt1-17
Categories	Elisa
Function	May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Specificity	Natural and recombinant Mouse Keratin, type I cytoskeletal 17
Subcellular Location	Cytoplasm
Detection Range	15.6-1000pg/mL
Entryname	K1C17_MOUSE
Method Type	Sandwich
Platform	PF00038
Protein Name	Keratin, type I cytoskeletal 17
Sensitivity	7.94pg/mL
Sequence	50: MTTTIRQFTS ; SSSIKGSSGL ; GGGSSRTSCR ; LSGSLGAGSC ; RLGSASGLGS ; 100: ALGSNSYSSC ; YSFGTGSGYG ; GNFGGVDGLL ; AGGEKATMQN ; LNDRLASYLD ; 150: KVRALEEANT ; ELEVKIRDWY ; QKQAPGPARD ; YSAYYHTIED ; LKNKILVATV ; 200: DNASILLQID ; NARLAADDFR ; TKFETEQALR ; MSVEADINGL ; RRVLDELTLA ; 250: RADLEMQIEN ; LKEELAYLKK ; NHEEEMNALR ; GQVGGEINVE ; MDAAPGVDLS ; 300: RILSEMRDQY ; EKMAEKNRKD ; AEDWFFSKTE ; ELNREVATNS ; ELVQSGKSEI ; 350: SELRRTMQAL ; EIELQSQLSM ; KASLEGSLAE ; TENRYCVQLS ; QIQGLIGSVE ; 400: EQLAQLRCEM ; EQQNQEYKIL ; LDVKTRLEQE ; IATYRRLLEG ; EDAHLTQYKP ; 433: KEPVTTRQVR ; TIVEEVQDGK ; VISSREQVHQ ; TTR
Sequence Length	433
String	Q9QWL7
Sub Unit	Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (By similarity). Interacts with TRADD and SFN.

Uniprot	Q9QWL7
Gene Name	Krt17
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16667
Unigene	Mm.14046

Reference	1. "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development." McGowan K.M., Coulombe P.A. J. Cell Biol.143:469-486(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];FUNCTION;DEVELOPMENTAL STAGE;INDUCTION strain: 129/SvJ. 2. "The genomic organization of type I keratin genes in mice." Sato H., Koide T., Sagai T., Ishiguro S., Tamai M., Saitou N., Shiroishi T. Genomics56:303-309(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/10J. tissue: Skin. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Lung. 5. Lubec G., Sunyer B., Chen W.-Q. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 95-101; 164-170; 285-297 AND 377-385;IDENTIFICATION BY MASS SPECTROMETRY strain: OF1. tissue: Hippocampus. 6. "Three cDNA sequences of mouse type I keratins: cellular localization of the mRNAs in normal and hyperproliferative tissues." Knapp B., Rentrop M., Schweizer J., Winter H. J. Biol. Chem.262:938-945(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-433;TISSUE SPECIFICITY;INDUCTION tissue: Skin. 7. "Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype." McGowan K.M., Coulombe P.A. J. Invest. Dermatol.114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 8. "In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting." Fan W., Yoon K. Exp. Dermatol.12:832-842(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;MUTAGENESIS OF ARG-94 9. "Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion." Tong X., Coulombe P.A. Genes Dev.20:1353-1364(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRADD;SUBCELLULAR LOCATION 10. "A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth." Kim S., Wong P., Coulombe P.A. Nature441:362-365(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SFN;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-9 AND SER-44

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