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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Iron-responsive element-binding protein 2

SKU : BHE13805757

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13568m
Alternative Names	Iron regulatory protein 2 ; IRP2 ; Irp2
Categories	Elisa
Function	RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Specificity	Natural and recombinant Mouse Iron-responsive element-binding protein 2
Subcellular Location	Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	IREB2_MOUSE
Method Type	Sandwich
Platform	PF00330
Protein Name	Iron-responsive element-binding protein 2
Sensitivity	0.089ng/mL
Sequence	50: MDSPSAGYTF ; EYLIETLNGN ; SQKKFFNVPK ; LGGTKYDILP ; YSIRVLLEAA ; 100: VRNCDGFLMK ; KEDVMNILDW ; KTKQSNVEVP ; FFPARVVLQD ; FTGIPAMVDF ; 150: AAMREAVKTL ; GGDPKKVHPA ; CPTDLTVDHS ; LQIDFSKCAI ; QNAPNPGGGD ; 200: LQKAGKLSPL ; KVQSKKLPCR ; GQTTCRGSCD ; SGELSRNSGT ; FSSQIENTPV ; 250: LCPFHLQPVP ; EPETVLKNQE ; VEFGRNRERL ; QFFKWSSGAF ; KNVAVIPPGT ; 300: GMAHQVNLEY ; LSRVVFEETD ; LLFPDSVVGT ; DSHITMVNGL ; GILGWGVGGI ; 350: ETEAVMLGLP ; VTLTLPEVVG ; CELTGSSNAF ; VTSIDIVLGI ; TKHLRQVGVA ; 400: GKFVEFFGSG ; VSQLSIVDRT ; TIANMCPEYG ; AILSFFPVDN ; VTLRHLEHTG ; 450: FDKTKLESME ; KYLKAVKLFR ; NDENSSEPEY ; SQVIQINLNS ; IVASVSGPKR ; 500: PQDRVAVTDM ; KSDFQACLNE ; KVGFKGFQVA ; AEKQSDTVSV ; RYDGSEYKLS ; 550: HGSVVIAAVI ; SCTNNCNPSV ; MLAAGLLAKK ; AVEIGLRVKP ; YIRTSLSPGS ; 600: GMVTHYLSSS ; GVLPYLSKLG ; FDIVGYGCST ; CVGNTAPLSE ; AVLNAVKQGD ; 650: LVTCGVLSGN ; KHFEGRLCDC ; VRANYLASPP ; LVVAYAIAGT ; VNIDFQTEPL ; 700: GTDSTGKEIY ; LHDIWPSREE ; VHQMEEEHVI ; LSMFKTLKEK ; VEMGNKRWNS ; 750: LEAPDSVLFP ; WDVKSTYIRC ; PSFFDKLTKE ; PAASQPIENA ; HVLLYLGDSV ; 800: TTDHISPAGS ; IARSSAAAKY ; LTNRGLTPRE ; FNSYGARRGN ; DAVMTRGTFA ; 850: NIKLFNKFIG ; KPAPKTIHFP ; SGQTLDVFEA ; AELYQKEGIP ; LIILAGKKYG ; 900: SGNSRDWAAK ; GPYLLGVKAV ; LAESYEKIHK ; DHLIGIGIAP ; LEFLPGENAD ; 950: SLGLSGREVF ; SLSFPEELFP ; GITLNIKTST ; GKEFSVIASF ; ANDVEITLYK ; 963: HGGLLNFVAR ; KFL
Sequence Length	963
String	Q811J3
Sub Unit	Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.

Uniprot	Q811J3
Gene Name	Ireb2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:64602
Unigene	Mm.208991

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Mammary tumor. 3. "Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line." Schalinske K.L., Blemings K.P., Steffen D.W., Chen O.S., Eisenstein R.S. Proc. Natl. Acad. Sci. U.S.A.94:10681-10686(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-214

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