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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Interleukin-4 receptor subunit alpha

SKU : BHE13806000

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2031m
Alternative Names	CD124 ; Il4ra
Categories	Elisa
Function	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Specificity	Natural and recombinant Mouse Interleukin-4 receptor subunit alpha
Subcellular Location	Isoform 2 Secreted
Detection Range	31.2-2000pg/mL
Entryname	IL4RA_MOUSE
Method Type	Sandwich
Platform	PF09238
Protein Name	Interleukin-4 receptor subunit alpha
Sensitivity	15.81pg/mL
Sequence	50: MGRLCTKFLT ; SVGCLILLLV ; TGSGSIKVLG ; EPTCFSDYIR ; TSTCEWFLDS ; 100: AVDCSSQLCL ; HYRLMFFEFS ; ENLTCIPRNS ; ASTVCVCHME ; MNRPVQSDRY ; 150: QMELWAEHRQ ; LWQGSFSPSG ; NVKPLAPDNL ; TLHTNVSDEW ; LLTWNNLYPS ; 200: NNLLYKDLIS ; MVNISREDNP ; AEFIVYNVTY ; KEPRLSFPIN ; ILMSGVYYTA ; 250: RVRVRSQILT ; GTWSEWSPSI ; TWYNHFQLPL ; IQRLPLGVTI ; SCLCIPLFCL ; 300: FCYFSITKIK ; KIWWDQIPTP ; ARSPLVAIII ; QDAQVPLWDK ; QTRSQESTKY ; 350: PHWKTCLDKL ; LPCLLKHRVK ; KKTDFPKAAP ; TKSLQSPGKA ; GWCPMEVSRT ; 400: VLWPENVSVS ; VVRCMELFEA ; PVQNVEEEED ; EIVKEDLSMS ; PENSGGCGFQ ; 450: ESQADIMARL ; TENLFSDLLE ; AENGGLGQSA ; LAESCSPLPS ; GSGQASVSWA ; 500: CLPMGPSEEA ; TCQVTEQPSH ; PGPLSGSPAQ ; SAPTLACTQV ; PLVLADNPAY ; 550: RSFSDCCSPA ; PNPGELAPEQ ; QQADHLEEEE ; PPSPADPHSS ; GPPMQPVESW ; 600: EQILHMSVLQ ; HGAAAGSTPA ; PAGGYQEFVQ ; AVKQGAAQDP ; GVPGVRPSGD ; 650: PGYKAFSSLL ; SSNGIRGDTA ; AAGTDDGHGG ; YKPFQNPVPN ; QSPSSVPLFT ; 700: FGLDTELSPS ; PLNSDPPKSP ; PECLGLELGL ; KGGDWVKAPP ; PADQVPKPFG ; 750: DDLGFGIVYS ; SLTCHLCGHL ; KQHHSQEEGG ; QSPIVASPGC ; GCCYDDRSPS ; 800: LGSLSGALES ; CPEGIPPEAN ; LMSAPKTPSN ; LSGEGKGPGH ; SPVPSQTTEV ; 810: PVGALGIAVS ;
Sequence Length	810
String	P16382
Sub Unit	The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Uniprot	P16382
Gene Name	Il4r
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16190
Unigene	Mm.233802

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806000	E2031m	96T	$776		Add to Cart

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