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ELISA Kit for Mouse Interferon regulatory factor 7

SKU : BHE13806181

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9556m
Categories	Elisa
Function	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
Specificity	Natural and recombinant Mouse Interferon regulatory factor 7
Subcellular Location	Nucleus Cytoplasm The phosphorylated and active form accumulates selectively in the nucleus.
Entryname	IRF7_MOUSE
Platform	PF00605
Protein Name	Interferon regulatory factor 7
Sequence	50: MAEVRGVQRV ; LFGDWLLGEV ; SSGQYEGLQW ; LNEARTVFRV ; PWKHFGRRDL ; 100: DEEDAQIFKA ; WAVARGRWPP ; SGVNLPPPEA ; EAAERRERRG ; WKTNFRCALH ; 150: STGRFILRQD ; NSGDPVDPHK ; VYELSRELGS ; TVGPATENRE ; EVSLSNALPT ; 200: QGVSPGSFLA ; RENAGLQTPS ; PLLSSDAGDL ; LLQVLQYSHI ; LESESGADPV ; 250: PPQAPGQEQD ; RVYEEPYAAW ; QVEAVPSPRP ; QQPALTERSL ; GFLDVTIMYK ; 300: GRTVLQAVVG ; HPRCVFLYSP ; MAPAVRTSEP ; QPVIFPSPAE ; LPDQKQLHYT ; 350: ETLLQHVSPG ; LQLELRGPSL ; WALRMGKCKV ; YWEVGSPMGT ; TGPSTPPQLL ; 400: ERNRHTPIFD ; FSTFFRELEE ; FRARRRQGSP ; HYTIYLGFGQ ; DLSAGRPKEK ; 450: TLILVKLEPW ; VCKAYLEGVQ ; REGVSSLDSS ; SLGLCLSSTN ; SLYEDIEHFL ; 457: MDLGQWP
Sequence Length	457
String	P70434
Sub Unit	Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6.

Uniprot	P70434
Gene Name	Irf7
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:54123
Unigene	Mm.3233

Reference	1. Grossman A., Nicholl J., Antonio L., Luethy R., Suggs S., Sutherland G.R., Mak T.W. Submitted (1996-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. tissue: Spleen. 2. "Structure and function of IRF-7." Zhang L., Pagano J.S. J. Interferon Cytokine Res.22:95-101(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION 3. "Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7." Caillaud A., Hovanessian A.G., Levy D.E., Marie I.J. J. Biol. Chem.280:17671-17677(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-425; SER-426; SER-429; SER-431; SER-437; SER-438 AND SER-441;MUTAGENESIS OF SER-425; SER-426; LEU-427; SER-429; SER-431; SER-437; SER-438 AND SER-441 4. "Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6." Kawai T., Sato S., Ishii K.J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., Akira S. Nat. Immunol.5:1061-1068(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;UBIQUITINATION;INTERACTION WITH MYD88 AND TRAF6 5. "IRF-7 is the master regulator of type-I interferon-dependent immune responses." Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., Taniguchi T. Nature434:772-777(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 6. "Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages." Solis M., Goubau D., Romieu-Mourez R., Genin P., Civas A., Hiscott J. Biochem. Pharmacol.72:1469-1476(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION 7. "Type I interferon gene induction by the interferon regulatory factor family of transcription factors." Honda K., Takaoka A., Taniguchi T. Immunity25:349-360(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION 8. Honda K., Takaoka A., Taniguchi T. Immunity25:849-849(2006) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM 9. "Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection." Daffis S., Samuel M.A., Suthar M.S., Keller B.C., Gale M. Jr., Diamond M.S. J. Virol.82:8465-8475(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 10. "Regulation of immunity and oncogenesis by the IRF transcription factor family." Savitsky D., Tamura T., Yanai H., Taniguchi T. Cancer Immunol. Immunother.59:489-510(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION 11. "IRF7: activation, regulation, modification and function." Ning S., Pagano J.S., Barber G.N. Genes Immun.12:399-414(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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