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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Interferon-induced helicase C domain-containing protein 1

SKU : BHE13805502

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2803m
Alternative Names	Helicase with 2 CARD domains ; Helicard ; Interferon induced with helicase C domain protein 1 ; Melanoma differentiation-associated protein 5 ; MDA-5 ; RIG-I-like receptor 2 ; RLR-2
Categories	Elisa
Function	RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA (By similarity). Essential for the production of interferons in response to picornaviruses.
Specificity	Natural and recombinant Mouse Interferon-induced helicase C domain-containing protein 1
Subcellular Location	Cytoplasm Nucleus May be found in the nucleus, during apoptosis.
Detection Range	31.2-2000pg/mL
Entryname	IFIH1_MOUSE
Method Type	Sandwich
Platform	PF00619
Protein Name	Interferon-induced helicase C domain-containing protein 1
Sensitivity	15.65pg/mL
Sequence	50: MSIVCSAEDS ; FRNLILFFRP ; RLKMYIQVEP ; VLDHLIFLSA ; ETKEQILKKI ; 100: NTCGNTSAAE ; LLLSTLEQGQ ; WPLGWTQMFV ; EALEHSGNPL ; AARYVKPTLT ; 150: DLPSPSSETA ; HDECLHLLTL ; LQPTLVDKLL ; INDVLDTCFE ; KGLLTVEDRN ; 200: RISAAGNSGN ; ESGVRELLRR ; IVQKENWFST ; FLDVLRQTGN ; DALFQELTGG ; 250: GCPEDNTDLA ; NSSHRDGPAA ; NECLLPAVDE ; SSLETEAWNV ; DDILPEASCT ; 300: DSSVTTESDT ; SLAEGSVSCF ; DESLGHNSNM ; GRDSGTMGSD ; SDESVIQTKR ; 350: VSPEPELQLR ; PYQMEVAQPA ; LDGKNIIICL ; PTGSGKTRVA ; VYITKDHLDK ; 400: KKQASESGKV ; IVLVNKVMLA ; EQLFRKEFNP ; YLKKWYRIIG ; LSGDTQLKIS ; 450: FPEVVKSYDV ; IISTAQILEN ; SLLNLESGDD ; DGVQLSDFSL ; IIIDECHHTN ; 500: KEAVYNNIMR ; RYLKQKLRNN ; DLKKQNKPAI ; PLPQILGLTA ; SPGVGAAKKQ ; 550: SEAEKHILNI ; CANLDAFTIK ; TVKENLGQLK ; HQIKEPCKKF ; VIADDTRENP ; 600: FKEKLLEIMA ; SIQTYCQKSP ; MSDFGTQHYE ; QWAIQMEKKA ; AKDGNRKDRV ; 650: CAEHLRKYNE ; ALQINDTIRM ; IDAYSHLETF ; YTDEKEKKFA ; VLNDSDKSDD ; 700: EASSCNDQLK ; GDVKKSLKLD ; ETDEFLMNLF ; FDNKKMLKKL ; AENPKYENEK ; 750: LIKLRNTILE ; QFTRSEESSR ; GIIFTKTRQS ; TYALSQWIME ; NAKFAEVGVK ; 800: AHHLIGAGHS ; SEVKPMTQTE ; QKEVISKFRT ; GEINLLIATT ; VAEEGLDIKE ; 850: CNIVIRYGLV ; TNEIAMVQAR ; GRARADESTY ; VLVTSSGSGV ; TEREIVNDFR ; 900: EKMMYKAINR ; VQNMKPEEYA ; HKILELQVQS ; ILEKKMKVKR ; SIAKQYNDNP ; 950: SLITLLCKNC ; SMLVCSGENI ; HVIEKMHHVN ; MTPEFKGLYI ; VRENKALQKK ; 1000: FADYQTNGEI ; ICKCGQAWGT ; MMVHKGLDLP ; CLKIRNFVVN ; FKNNSPKKQY ; 1025: KKWVELPIRF ; PDLDYSEYCL ; YSDED
Sequence Length	1025
String	Q8R5F7
Sub Unit	Interacts with MAVS. Interacts with V protein of Sendai virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state (By similarity). Interacts with PCBP2 (By similarity). Interacts with NLRC5.

Uniprot	Q8R5F7
Gene Name	Ifih1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:71586
Unigene	Mm.136224

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805502	E2803m	96T	$776		Add to Cart

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