JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Insulin receptor substrate 4

SKU : BHE13806547

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0288m
Alternative Names	Phosphoprotein of 160 kDa ; pp160
Categories	Elisa
Function	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.
Specificity	Natural and recombinant Mouse Insulin receptor substrate 4
Subcellular Location	Cell membrane Peripheral membrane protein Cytoplasmic side
Detection Range	0.156-10ng/mL
Entryname	IRS4_MOUSE
Method Type	Sandwich
Platform	PF02174
Protein Name	Insulin receptor substrate 4
Sensitivity	0.078ng/mL
Sequence	50: MASCSFSGHQ ; ALRRLRASAA ; AAASAALAAV ; ATTPLLSSGT ; RTALIGTGSS ; 100: CPGAMWLSTA ; TGSRSDSESE ; EEDLPVGDEV ; CKRGYLRKQK ; HGHRRYFVLK ; 150: LETADAPARL ; EYYRNARKFR ; HSVRAAAAAA ; EAAASGAAVP ; ALIPPRRVII ; 200: LYQCFSVSQR ; ADARYRHLIA ; LFTQDEYFAM ; VAENESEQES ; WYLLLSRLIL ; 250: ESKRRRCGTL ; GALPDGEPAA ; LAAAAAAEPP ; FYKDVWQVVV ; KPRGLGHRKE ; 300: LSGVFRLCLT ; DEEVVFVRLN ; TEVASVVVQL ; LSIRRCGHSE ; QYFFLEVGRS ; 350: TVIGPGELWM ; QVDDSVVAQN ; MHELFLEKMR ; ALCADEYRAR ; CRSYSISIGA ; 400: HLLTLLSTRR ; HLGLLPLEPG ; GWLRRYGLEQ ; FCRLRAIRER ; EEMLFTRRFI ; 450: SPREPPPPFR ; RGRGHLPRAR ; RSRRAASVPP ; SLFRRSAPSP ; GRIPQPEDVP ; 500: NDRAREASGS ; SSGNTEEKDK ; EGEEGNRGDC ; IPMNNWGSGN ; GRGSGGGRGS ; 550: SGQGSSSQGS ; GGRQGSGGGQ ; GSGGQGAGGN ; QCSGNGQGTA ; GGHGSGGGGH ; 600: GSGGGQRPGD ; GHGSGGGKNS ; GSGKNSDDGD ; RGKSVKKRSY ; FGKFTQSKQQ ; 650: QTLPPPPPPP ; PAAGATGGKG ; KSGGRFRLYF ; CADRGTKERK ; EAKEVRDMET ; 700: SGGATRGPYR ; ARAFDEDEDD ; PYVPMRPGVA ; APLACSSDYM ; PMAPQNSSAS ; 750: TKRHSRSPFE ; DSRGYMMMFP ; RVSPPPPVPS ; APKAPDTNKG ; DDSKDNDSDS ; 800: DYMFMAPGAG ; AIPKNPPNAQ ; GGSSSKSWSS ; YFSLPSPFQS ; SPLGQSDHSE ; 850: YVPMLPGKFL ; GSGLHKEASF ; SQGTKNVSSK ; PSTEASFSKP ; EDKGSSAKPS ; 900: DDVPPMNKAK ; EPNHLSFIAK ; GTQVKPKPLN ; PTQERREAAG ; SRDYINIDFI ; 950: KRERLVLPSS ; AQGLPDMRGV ; VTDPAPTAFS ; GYLNVEFGVP ; FPNPTIRLSD ; 1000: LLRVLPGANS ; IPLAGTRWPF ; PGSAIGSIVE ; AGEYIEVIFN ; PAMTPAMSFA ; 1050: DSAICYDAQT ; GQIYVVDPFS ; ECCMDVSLSP ; GRCSEPPPVA ; RLRREEAQER ; 1100: RRPQSRSQSL ; FASTRAAVSA ; FPTDSLDRDF ; PAASAVIAAP ; AEAPLLAVSR ; 1150: ALAVVSALAA ; APSIGDVFAG ; FRAAAGVDSA ; SARGFQPVAG ; AQAVREFQDL ; 1200: AAGWNPGALN ; HRARGEDLAA ; GAAAPPPPPR ; QIWVLRPQER ; ADSEDDDDDD ; 1216: DDIYVRMDFA ; RRDYRK
Sequence Length	1216
String	Q9Z0Y7
Sub Unit	Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH (By similarity). Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2.

Uniprot	Q9Z0Y7
Gene Name	Irs4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16370
Unigene	Mm.261591

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13806547	E0288m	96T	$776		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.