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ELISA Kit for Mouse Insulin receptor substrate 1

SKU : BHE13805099

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1660m
Alternative Names	Irs-1
Categories	Elisa
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Specificity	Natural and recombinant Mouse Insulin receptor substrate 1
Detection Range	0.312-20ng/mL
Entryname	IRS1_MOUSE
Method Type	Sandwich
Platform	PF02174
Protein Name	Insulin receptor substrate 1
Sensitivity	0.171ng/mL
Sequence	50: MASPPDTDGF ; SDVRKVGYLR ; KPKSMHKRFF ; VLRAASEAGG ; PARLEYYENE ; 100: KKWRHKSSAP ; KRSIPLESCF ; NINKRADSKN ; KHLVALYTRD ; EHFAIAADSE ; 150: AEQDSWYQAL ; LQLHNRAKAH ; HDGAGGGCGG ; SCSGSSGVGE ; AGEDLSYDTG ; 200: PGPAFKEVWQ ; VILKPKGLGQ ; TKNLIGIYRL ; CLTSKTISFV ; KLNSEAAAVV ; 250: LQLMNIRRCG ; HSENFFFIEV ; GRSAVTGPGE ; FWMQVDDSVV ; AQNMHETILE ; 300: AMRAMSDEFR ; PRSKSQSSSS ; CSNPISVPLR ; RHHLNNPPPS ; QVGLTRRSRT ; 350: ESITATSPAS ; MVGGKPGSFR ; VRASSDGEGT ; MSRPASVDGS ; PVSPSTNRTH ; 400: AHRHRGSSRL ; HPPLNHSRSI ; PMPSSRCSPS ; ATSPVSLSSS ; STSGHGSTSD ; 450: CLFPRRSSAS ; VSGSPSDGGF ; ISSDEYGSSP ; CDFRSSFRSV ; TPDSLGHTPP ; 500: ARGEEELSNY ; ICMGGKGAST ; LAAPNGHYIL ; SRGGNGHRYI ; PGANLGTSPA ; 550: LPGDEAAGAA ; DLDNRFRKRT ; HSAGTSPTIS ; HQKTPSQSSV ; ASIEEYTEMM ; 600: PAAYPPGGGS ; GGRLPGYRHS ; AFVPTHSYPE ; EGLEMHHLER ; RGGHHRPDTS ; 650: NLHTDDGYMP ; MSPGVAPVPS ; NRKGNGDYMP ; MSPKSVSAPQ ; QIINPIRRHP ; 700: QRVDPNGYMM ; MSPSGSCSPD ; IGGGSSSSSS ; ISAAPSGSSY ; GKPWTNGVGG ; 750: HHTHALPHAK ; PPVESGGGKL ; LPCTGDYMNM ; SPVGDSNTSS ; PSECYYGPED ; 800: PQHKPVLSYY ; SLPRSFKHTQ ; RPGEPEEGAR ; HQHLRLSSSS ; GRLRYTATAE ; 850: DSSSSTSSDS ; LGGGYCGARP ; ESSLTHPHHH ; VLQPHLPRKV ; DTAAQTNSRL ; 900: ARPTRLSLGD ; PKASTLPRVR ; EQQQQQQSSL ; HPPEPKSPGE ; YVNIEFGSGQ ; 950: PGYLAGPATS ; RSSPSVRCPP ; QLHPAPREET ; GSEEYMNMDL ; GPGRRATWQE ; 1000: SGGVELGRIG ; PAPPGSATVC ; RPTRSVPNSR ; GDYMTMQIGC ; PRQSYVDTSP ; 1050: VAPVSYADMR ; TGIAAEKASL ; PRPTGAAPPP ; SSTASSSASV ; TPQGATAEQA ; 1100: THSSLLGGPQ ; GPGGMSAFTR ; VNLSPNHNQS ; AKVIRADTQG ; CRRRHSSETF ; 1150: SAPTRAGNTV ; PFGAGAAVGG ; SGGGGGGGSE ; DVKRHSSASF ; ENVWLRPGDL ; 1200: GGVSKESAPV ; CGAAGGLEKS ; LNYIDLDLAK ; EHSQDCPSQQ ; QSLPPPPPHQ ; 1233: PLGSNEGNSP ; RRSSEDLSNY ; ASISFQKQPE ; DRQ
Sequence Length	1233
String	P35569
Sub Unit	Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF and PIK3CA. Interacts (via PH domain) with PHIP. Interacts with FER. Interacts with ALK.

Uniprot	P35569
Gene Name	Irs1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16367
Unigene	Mm.4952

Reference	1. "Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1." Araki E., Haag B.L. III, Kahn C.R. Biochim. Biophys. Acta1221:353-356(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning." Keller S.R., Aebersold R., Garner C.W., Lienhard G.E. Biochim. Biophys. Acta1172:323-326(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase." Iwanishi M., Czech M.P., Cherniack A.D. J. Biol. Chem.275:38995-39000(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FER 4. "Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein." Farhang-Fallah J., Yin X., Trentin G., Cheng A.M., Rozakis-Adcock M. J. Biol. Chem.275:40492-40497(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHIP 5. "Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover." Ogata N., Chikazu D., Kubota N., Terauchi Y., Tobe K., Azuma Y., Ohta T., Kadowaki T., Nakamura K., Kawaguchi H. J. Clin. Invest.105:935-943(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 6. "5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside." Jakobsen S.N., Hardie D.G., Morrice N., Tornqvist H.E. J. Biol. Chem.276:46912-46916(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-789 7. "Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase." Drakas R., Tu X., Baserga R. Proc. Natl. Acad. Sci. U.S.A.101:9272-9276(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBTF AND PIK3CA;EFFECT ON CELL AND BODY SIZE 8. "Role of Rho-kinase in regulation of insulin action and glucose homeostasis." Furukawa N., Ongusaha P., Jahng W.J., Araki K., Choi C.S., Kim H.J., Lee Y.H., Kaibuchi K., Kahn B.B., Masuzaki H., Kim J.K., Lee S.W., Kim Y.B. Cell Metab.2:119-129(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-632 9. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 AND SER-1097;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver. 10. "Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice." Carvalho-Filho M.A., Carvalho B.M., Oliveira A.G., Guadagnini D., Ueno M., Dias M.M., Tsukumo D.M., Hirabara S.M., Reis L.F., Curi R., Carvalheira J.B., Saad M.J. Endocrinology153:5261-5274(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF2AK2

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