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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

SKU : BHE13806072

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1200m
Alternative Names	Insulin-like growth factor I receptor ; IGF-I receptor ; CD221
Categories	Elisa
Function	This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Specificity	Natural and recombinant Mouse Insulin-like growth factor 1 receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.312-20ng/mL
Entryname	IGF1R_MOUSE
Method Type	Sandwich
Platform	PF00041
Protein Name	Insulin-like growth factor 1 receptor
Sensitivity	0.161ng/mL
Sequence	50: MKSGSGGGSP ; TSLWGLVFLS ; AALSLWPTSG ; EICGPGIDIR ; NDYQQLKRLE ; 100: NCTVIEGFLH ; ILLISKAEDY ; RSYRFPKLTV ; ITEYLLLFRV ; AGLESLGDLF ; 150: PNLTVIRGWK ; LFYNYALVIF ; EMTNLKDIGL ; YNLRNITRGA ; IRIEKNADLC ; 200: YLSTIDWSLI ; LDAVSNNYIV ; GNKPPKECGD ; LCPGTLEEKP ; MCEKTTINNE ; 250: YNYRCWTTNR ; CQKMCPSVCG ; KRACTENNEC ; CHPECLGSCH ; TPDDNTTCVA ; 300: CRHYYYKGVC ; VPACPPGTYR ; FEGWRCVDRD ; FCANIPNAES ; SDSDGFVIHD ; 350: DECMQECPSG ; FIRNSTQSMY ; CIPCEGPCPK ; VCGDEEKKTK ; TIDSVTSAQM ; 400: LQGCTILKGN ; LLINIRRGNN ; IASELENFMG ; LIEVVTGYVK ; IRHSHALVSL ; 450: SFLKNLRLIL ; GEEQLEGNYS ; FYVLDNQNLQ ; QLWDWNHRNL ; TVRSGKMYFA ; 500: FNPKLCVSEI ; YRMEEVTGTK ; GRQSKGDINT ; RNNGERASCE ; SDVLRFTSTT ; 550: TWKNRIIITW ; HRYRPPDYRD ; LISFTVYYKE ; APFKNVTEYD ; GQDACGSNSW ; 600: NMVDVDLPPN ; KEGEPGILLH ; GLKPWTQYAV ; YVKAVTLTMV ; ENDHIRGAKS ; 650: EILYIRTNAS ; VPSIPLDVLS ; ASNSSSQLIV ; KWNPPTLPNG ; NLSYYIVRWQ ; 700: RQPQDGYLYR ; HNYCSKDKIP ; IRKYADGTID ; VEEVTENPKT ; EVCGGDKGPC ; 750: CACPKTEAEK ; QAEKEEAEYR ; KVFENFLHNS ; IFVPRPERRR ; RDVMQVANTT ; 800: MSSRSRNTTV ; ADTYNITDPE ; EFETEYPFFE ; SRVDNKERTV ; ISNLRPFTLY ; 850: RIDIHSCNHE ; AEKLGCSASN ; FVFARTMPAE ; GADDIPGPVT ; WEPRPENSIF ; 900: LKWPEPENPN ; GLILMYEIKY ; GSQVEDQREC ; VSRQEYRKYG ; GAKLNRLNPG ; 950: NYTARIQATS ; LSGNGSWTDP ; VFFYVPAKTT ; YENFMHLIIA ; LPVAILLIVG ; 1000: GLVIMLYVFH ; RKRNNSRLGN ; GVLYASVNPE ; YFSAADVYVP ; DEWEVAREKI ; 1050: TMNRELGQGS ; FGMVYEGVAK ; GVVKDEPETR ; VAIKTVNEAA ; SMRERIEFLN ; 1100: EASVMKEFNC ; HHVVRLLGVV ; SQGQPTLVIM ; ELMTRGDLKS ; YLRSLRPEVE ; 1150: QNNLVLIPPS ; LSKMIQMAGE ; IADGMAYLNA ; NKFVHRDLAA ; RNCMVAEDFT ; 1200: VKIGDFGMTR ; DIYETDYYRK ; GGKGLLPVRW ; MSPESLKDGV ; FTTHSDVWSF ; 1250: GVVLWEIATL ; AEQPYQGLSN ; EQVLRFVMEG ; GLLDKPDNCP ; DMLFELMRMC ; 1300: WQYNPKMRPS ; FLEIIGSIKD ; EMEPSFQEVS ; FYYSEENKPP ; EPEELEMELE ; 1350: MEPENMESVP ; LDPSASSASL ; PLPERHSGHK ; AENGPGPGVL ; VLRASFDERQ ; 1373: PYAHMNGGRA ; NERALPLPQS ; STC
Sequence Length	1373
String	Q60751
Sub Unit	Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1.

Uniprot	Q60751
Gene Name	Igf1r
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16001
Unigene	Mm.275742

Reference	1. "Cloning of cDNA for the mouse insulin-like growth factor I receptor." Navarro M., Garandel V., Barenton B., Bernardi H. Submitted (1998-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development." Wada J., Liu Z.Z., Alvares K., Kumar A., Wallner E.I., Makino H., Kanwar Y.S. Proc. Natl. Acad. Sci. U.S.A.90:10360-10364(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-329 strain: CD-1. tissue: Kidney. 3. "The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family." Wilks A.F., Kurban R.R., Hovens C.M., Ralph S.J. Gene85:67-74(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1134-1203 4. "Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)." Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. Cell75:59-72(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 5. "Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts." Buckley D.A., Cheng A., Kiely P.A., Tremblay M.L., O'Connor R. Mol. Cell. Biol.22:1998-2010(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION 6. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-748 AND ASN-901 tissue: Myoblast. 7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-639; ASN-641; ASN-757 AND ASN-765 8. "Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth." Kelly G.M., Buckley D.A., Kiely P.A., Adams D.R., O'Connor R. J. Biol. Chem.287:28180-28194(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1280 AND SER-1284

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