Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
Specificity
Natural and recombinant Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Subcellular Location
Cytoplasm Nucleus Nucleus PML body Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent.
May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD.