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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse ICOS ligand

SKU : BHE13805740

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15092m
Alternative Names	B7 homolog 2 ; B7-H2 ; B7-like protein Gl50 ; B7-related protein 1 ; B7RP-1 ; LICOS ; CD275 ; B7h2 ; B7rp1 ; Icosl
Categories	Elisa
Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Specificity	Natural and recombinant Mouse ICOS ligand
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/mL
Entryname	ICOSL_MOUSE
Method Type	Sandwich
Platform	PF08205
Protein Name	ICOS ligand
Sensitivity	0.095ng/mL
Sequence	50: MQLKCPCFVS ; LGTRQPVWKK ; LHVSSGFFSG ; LGLFLLLLSS ; LCAASAETEV ; 100: GAMVGSNVVL ; SCIDPHRRHF ; NLSGLYVYWQ ; IENPEVSVTY ; YLPYKSPGIN ; 150: VDSSYKNRGH ; LSLDSMKQGN ; FSLYLKNVTP ; QDTQEFTCRV ; FMNTATELVK ; 200: ILEEVVRLRV ; AANFSTPVIS ; TSDSSNPGQE ; RTYTCMSKNG ; YPEPNLYWIN ; 250: TTDNSLIDTA ; LQNNTVYLNK ; LGLYDVISTL ; RLPWTSRGDV ; LCCVENVALH ; 300: QNITSISQAE ; SFTGNNTKNP ; QETHNNELKV ; LVPVLAVLAA ; AAFVSFIIYR ; 322: RTRPHRSYTG ; PKTVQLELTD ; HA
Sequence Length	322
String	Q9JHJ8

Uniprot	Q9JHJ8
Gene Name	Icoslg
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:50723
Unigene	Mm.17819

Reference	1. "T-cell co-stimulation through B7RP-1 and ICOS." Yoshinaga S.K., Whoriskey J.S., Khare S.D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M.A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dai T., Duncan G., Elliott G.S., Hui A., McCabe S.M., Scully S., Shahinian A., Shaklee C.L., Van G., Mak T.W., Senaldi G.more... Nature402:827-832(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1);CHARACTERIZATION tissue: Lymphocyte. 2. "B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha." Swallow M.M., Wallin J.J., Sha W.C. Immunity11:423-432(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1) tissue: Thymus. 3. "Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor." Ling V., Wu P.W., Finnerty H.F., Bean K.M., Spaulding V., Fouser L.A., Leonard J.P., Hunter S.E., Zollner R., Thomas J.L., Miyashiro J.S., Jacobs K.A., Collins M. J. Immunol.164:1653-1657(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1) strain: C3H/HeJ. tissue: Fetal thymus. 4. "Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse gl50-b and human gl50 molecules." Ling V., Wu P.W., Miyashiro J.S., Marusic S., Finnerty H.F., Collins M. J. Immunol.166:7300-7308(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2) tissue: Peripheral blood lymphocyte. 5. "Gl50 molecules and uses therefor." Ling V., Dunussi-Joannopolulos K. [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2) 6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) strain: FVB/N. tissue: Colon.

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BHE13805740	E15092m	96T	$776		Add to Cart

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