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ELISA Kit for Mouse Histone deacetylase 9

SKU : BHE13805313

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11380m
Alternative Names	Histone deacetylase 7B ; HD7b ; Histone deacetylase-related protein ; MEF2-interacting transcription repressor MITR ; Hdac7b ; Hdrp ; Mitr
Categories	Elisa
Function	Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Specificity	Natural and recombinant Mouse Histone deacetylase 9
Subcellular Location	Nucleus
Entryname	HDAC9_MOUSE
Platform	PF12203
Protein Name	Histone deacetylase 9
Sequence	50: MHSMISSVDV ; KSEVPMGLEP ; ISPLDLRTDL ; RMMMPVVDPV ; VREKQLQQEL ; 100: LLIQQQQQIQ ; KQLLIAEFQK ; QHENLTRQHQ ; AQLQEHIKEL ; LAIKQQQELL ; 150: EKEQKLEQQR ; QEQEVERHRR ; EQQLPPLRGK ; DRGRERAVAS ; TEVKQKLQEF ; 200: LLSKSATKDT ; PTNGKNHSVG ; RHPKLWYTAA ; HHTSLDQSSP ; PLSGTSPSYK ; 250: YTLPGAQDSK ; DDFPLRKTAS ; EPNLKVRSRL ; KQKVAERRSS ; PLLRRKDGNL ; 300: VTSFKKRVFE ; VAESSVSSSS ; PGSGPSSPNN ; GPAGNVTENE ; ASALPPTPHP ; 350: EQLVPQQRIL ; IHEDSMNLLS ; LYTSPSLPNI ; TLGLPAVPSP ; LNASNSLKDK ; 400: QKCETQMLRQ ; GVPLPSQYGS ; SIAASSSHVH ; VAMEGKPNSS ; HQALLQHLLL ; 450: KEQMRQQKLL ; VAGGVPLHPQ ; SPLATKERIS ; PGIRGTHKLP ; RHRPLNRTQS ; 500: APLPQSTLAQ ; LVIQQQHQQF ; LEKQKQYQQQ ; IHMNKLLSKS ; IEQLKQPGSH ; 550: LEEAEEELQG ; DQSMEDRAAS ; KDNSARSDSS ; ACVEDTLGQV ; GAVKVKEEPV ; 588: DSDEDAQIQE ; MECGEQAAFM ; QQVIGKDLAP ; GFVIKVII
Sequence Length	588
String	Q99N13
Sub Unit	Homodimer. Interacts with ETV6 (By similarity). Interacts with MEF2, HDAC1, HDAC3, HDAC4, HDAC5, CTBP1 and MAPK10. The phosphorylated form interacts with 14-3-3.

Uniprot	Q99N13
Gene Name	Hdac9
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:79221
Unigene	Mm.310551

Reference	1. "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor." Zhang C.L., McKinsey T.A., Lu J.R., Olson E.N. J. Biol. Chem.276:35-39(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);HOMODIMERIZATION;INTERACTION WITH CTBP1; HDAC1; HDAC3; HDAC4 AND HDAC5;MUTAGENESIS OF 25-ASP-LEU-26 strain: NIH Swiss. tissue: Embryonic heart. 2. "Cloning of the mouse HDRP cDNA." Zhou X., Richon V.M., Rifkind R.A., Marks P.A. Submitted (2000-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2) strain: Swiss Webster / NIH. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) strain: C57BL/6. tissue: Retina. 4. "The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis." Zhang C.L., McKinsey T.A., Olson E.N. Proc. Natl. Acad. Sci. U.S.A.98:7354-7359(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-220 AND SER-450;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION 5. "Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy." Zhang C.L., McKinsey T.A., Chang S., Antos C.L., Hill J.A., Olson E.N. Cell110:479-488(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-220 AND SER-450;FUNCTION;DISRUPTION PHENOTYPE 6. "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation." Deng X., Ewton D.Z., Mercer S.E., Friedman E. J. Biol. Chem.280:4894-4905(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-240;SUBCELLULAR LOCATION 7. "Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression." Mejat A., Ramond F., Bassel-Duby R., Khochbin S., Olson E.N., Schaeffer L. Nat. Neurosci.8:313-321(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DOWN-REGULATION BY DENERVATION;INTERACTION WITH HDAC1 AND HDAC3;SUBCELLULAR LOCATION 8. "Neuroprotection by histone deacetylase-related protein." Morrison B.E., Majdzadeh N., Zhang X., Lyles A., Bassel-Duby R., Olson E.N., D'Mello S.R. Mol. Cell. Biol.26:3550-3564(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION BY NEURONAL APOPTOSIS;FUNCTION;INTERACTION WITH HDAC1 AND MAPK10 9. "Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation." Haberland M., Arnold M.A., McAnally J., Phan D., Kim Y., Olson E.N. Mol. Cell. Biol.27:518-525(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY MEF2;DEVELOPMENTAL STAGE 10. "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2." Han A., He J., Wu Y., Liu J.O., Chen L. J. Mol. Biol.345:91-102(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 139-158 IN COMPLEX WITH MEF2 AND DNA

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