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ELISA Kit for Mouse Histone acetyltransferase p300

SKU : BHE13803373

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15334m
Alternative Names	E1A-associated protein p300 ; P300
Categories	Elisa
Function	Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Acetylates the 'Lys-131' residue of ALX1 and acts as its coactivator in the presence of CREBBP. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of BETA2-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement.
Specificity	Natural and recombinant Mouse Histone acetyltransferase p300
Subcellular Location	Cytoplasm Nucleus In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Co-localizes with ROCK2 in the nucleus.
Entryname	EP300_MOUSE
Platform	PF00439
Protein Name	Histone acetyltransferase p300
Sequence	50: MAENVVEPGP ; PSAKRPKLSS ; PALSASASDG ; TDFGSLFDLE ; HDLPDELINS ; 100: TELGLTNGGD ; ISQLQTSLGI ; VQDAASKHKQ ; LSELLRSGSS ; PNLNMGVGGP ; 150: GQAMASQAQQ ; NSPGLSLINS ; MVKSPMAQTG ; LTSPNMGIGS ; SGPNQGPTQS ; 200: PAGMMNSPVN ; QPAMGMNTGM ; NAGMNPGMLA ; AGNGQGIMPN ; QVMNGSIGAG ; 250: RGRPNMQYPN ; AGMGNAGSLL ; TEPLQQGSPQ ; MGGQPGLRGP ; QPLKMGMMNN ; 300: PSPYGSPYTQ ; NSGQQIGASG ; LGLQIQTKTV ; LPNNLSPFAM ; DKKAVPGGGM ; 350: PSMGQQPTPS ; VQQPGLVTPV ; AAGMGSGAHT ; ADPEKRKLIQ ; QQLVLLLHAH ; 400: KCQRREQANG ; EVRQCNLPHC ; RTMKNVLNHM ; THCQSGKSCQ ; VAHCASSRQI ; 450: ISHWKNCTRH ; DCPVCLPLKN ; AGDKRNQQSI ; LTGAPVGLGN ; PSSLGVGQQS ; 500: TPSLSTVSQI ; DPSSIERAYA ; ALGLPYQVNQ ; IPPQPQVQAK ; NQQSQPSGQS ; 550: PQGMRSVNNM ; SASPMGVNGG ; VGVQTPNLLS ; DSMLHSTINS ; QNPMMSENAG ; 600: VASLGPLPTA ; AQPSSTGIRK ; QWHEDITQDL ; RNHLVHKLVQ ; AIFPTPDPAA ; 650: LKDRRMENLV ; AYARKVEGDM ; YESANNRAEY ; YHLLAEKIYK ; IQKELEEKRR ; 700: TRLQKQNMLP ; NAPGMGPVPM ; NTGSNMEQQP ; TGMTTNGPVP ; DPSMIRGSVP ; 750: NHMMPRMTPQ ; PGLNQFGQMN ; MPQPPIGPRQ ; PSPLQHHGQL ; AQSGSLNPPM ; 800: GYGPRMQQAS ; GQNQFLSQTQ ; FTSQGMNVTN ; MPLAPSSGQA ; PVSQAQMSSS ; 850: SCPVNSPIMP ; PGSQGSHIHC ; PTLPQQAHQN ; SPSPVPSRTP ; TPHHTPPSIG ; 900: NQPPPATAIP ; TPVPTPPAIP ; PGPQPPSLHP ; SSRQTPTPPT ; HLPPQVQPSL ; 950: PAAPSADQSQ ; QQPRSQQSTA ; VSVPTPTAPL ; LPPQPSTPLS ; QPAVSIEGQV ; 1000: SNPPSTSSTE ; VNSQTIPEKQ ; PSQEVKMESK ; MEVDKPEPAD ; AQPEDTKEAK ; 1050: GEDVKVEPTE ; MEERGPELKT ; DGKEEEEQPS ; TSATQSSPAP ; GQSKKKIFKP ; 1100: EELRQALMPT ; LEALYRQDPE ; SLPFRQPVDP ; QLLGIPDYFD ; IVKSPMDLST ; 1150: IKRKLDTGQY ; QEPWQYIDDI ; WLMFNNAWLY ; NRKTSRVYKY ; CSKLSEVFEQ ; 1200: EIDPVMQSLG ; YCCGRKLEFS ; PQTLCCYGKQ ; LCTIPRDATY ; YSYQNRYHFC ; 1250: EKCFNEIQGE ; SVSLGDDPSQ ; PQTTINKEQF ; SKRKNDTLDP ; ELFVECTECG ; 1300: RKMHQICVLH ; HEIIWPSGFV ; CDGCLKKTAR ; TRKENKLSAK ; RLPSTRLGTF ; 1350: LENRVNDFLR ; RQNHPESGEV ; TVRVVHASDK ; TVEVKPGMKA ; RFVDSGEMAE ; 1400: SFPYRTKALF ; AFEEIDGVDL ; CFFGMHVQEY ; GSDCPPPNQR ; RVYISYLDSV ; 1450: HFFRPKCLRT ; AVYHEILIGY ; LEYVKKLGYT ; TGHIWACPPS ; EGDDYIFHCH ; 1500: PPDQKIPKPK ; RLQEWYKKML ; DKAVSERIVH ; DYKDILKQAT ; EDRLTSAKEL ; 1550: PYFEGDFWPN ; VLEESIKELE ; QEEEERKREE ; NTSNESTDVT ; KGDSKNAKKK ; 1600: NNKKTSKNKS ; SLSRGNKKKP ; GMPNVSNDLS ; QKLYATMEKH ; KEVFFVIRLI ; 1650: ACPAPNSLPP ; IVDPDPLIPC ; DLMDGRDAFL ; TLARDKHLEF ; SSLRRAQWST ; 1700: MCMLVELHTQ ; SQDRFVYTCN ; ECKHHVETRW ; HCTVCEDYDL ; CITCYNTKNH ; 1750: DHKMEKLGLG ; LDDESNNQQA ; AATQSPGDSR ; RLSIQRCIQS ; LVHACQCRNA ; 1800: NCSLPSCQKM ; KRVVQHTKGC ; KRKTNGGCPI ; CKQLIALCCY ; HAKHCQENKC ; 1850: PVPFCLNIKQ ; KLRQQQLQHR ; LQQAQMLRRR ; MASMQRTGVA ; GQQQGLPSPT ; 1900: PATPTTPTGQ ; QPATPQTPQP ; QPTSQPQPTP ; PNNMTPYLPR ; TQTTGPVSQG ; 1950: KAPGQVTPPT ; PPQTAQAPLP ; GPPPAAVEMA ; MQIQRAAETQ ; RQMAHVQIFQ ; 2000: RPIQHQMPQM ; SPMAPMGMNP ; PPMARGPGGH ; LDPGIGPAGM ; QQQPPWAQGG ; 2050: MPQPQQMQSG ; MPRPAMMSVA ; QHGQPLNMAP ; QPGLGQVGVS ; PLKPGTVSQQ ; 2100: ALQNLLRTLR ; SPSSPLQQQQ ; VLSILHANPQ ; LLAAFIKQRA ; AKYANPNPQP ; 2150: LPGQPGMTQG ; QPGLQPPTMP ; GQQGVHSNPA ; LQNMNPLQAG ; VQRAGLPQQQ ; 2200: PQQQLQPPMG ; AMSPQAQQMN ; MNHNTMPSQF ; RDILRRQMMQ ; QQGAGPGIGP ; 2250: GMANQFQQPQ ; GIGYPPQQQQ ; QQQQQRMQHH ; MQQMQQGNMG ; QMGQLPQALG ; 2300: AEAGASLQAY ; QQRLLQQQMG ; SPAQPNPMSP ; QQHMLPNQAQ ; SPHLQGQQIP ; 2350: NSLSNQVRSP ; QPVPSPRPQS ; QPPHSSPSPR ; MQPQPSPHHV ; SPQTSSPHPG ; 2400: LVAAQAANPM ; EQGHFASPDQ ; NSMLSQLASN ; PGMANLHGAS ; ATDLGLSSDN ; 2415: ADLNSNLSQS ; TLDIH
Sequence Length	2415
String	B2RWS6
Sub Unit	Interacts with phosphorylated CREB1. Interacts with HIF1A; the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1 (unphosphorylated form preferentially and via C-terminus). Interacts with ESR1; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with HIPK2, DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, SATB1, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2. Interacts with TCF3. Interacts with PPARG (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes (By similarity). Interacts with CITED1 and CITED2. Interacts with ROCK2 (By similarity). Interacts with NEUROD1. Interacts (via CREB-binding domain) with MYOCD (via C-terminus).

Uniprot	B2RWS6
Gene Name	Ep300
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.258397

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. 3. "The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells." Mutoh H., Naya F.J., Tsai M.J., Leiter A.B. Genes Dev.12:820-830(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEUROD1 4. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression." Glenn D.J., Maurer R.A. J. Biol. Chem.274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED2 5. "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors." Yahata T., de Caestecker M.P., Lechleider R.J., Andriole S., Roberts A.B., Isselbacher K.J., Shioda T. J. Biol. Chem.275:8825-8834(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED1 6. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock." Curtis A.M., Seo S.B., Westgate E.J., Rudic R.D., Smyth E.M., Chakravarti D., FitzGerald G.A., McNamara P. J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NPAS2 7. "Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin." Cao D., Wang Z., Zhang C.L., Oh J., Xing W., Li S., Richardson J.A., Wang D.Z., Olson E.N. Mol. Cell. Biol.25:364-376(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOCD 8. "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation." Aikawa Y., Nguyen L.A., Isono K., Takakura N., Tagata Y., Schmitz M.L., Koseki H., Kitabayashi I. EMBO J.25:3955-3965(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIPK2;PHOSPHORYLATION BY HIPK2 9. "The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression." Ohoka N., Kato S., Takahashi Y., Hayashi H., Sato R. Mol. Endocrinol.23:759-771(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CEBPB;SUBCELLULAR LOCATION 10. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways." Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y. Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1179; LYS-1557 AND LYS-1559;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic fibroblast.

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