The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Specificity
Natural and recombinant Mouse Histamine H4 receptor
"Comparison of human, mouse, rat, and guinea pig histamine H4 receptor suggests substantial species variation." Liu C., Wilson S., Kuei C., Lovenberg T.W. Submitted (2001-03) to the EMBL/GenBank/DDBJ databases
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