When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
Specificity
Natural and recombinant Mouse Hepatitis B virus X-interacting protein homolog
QAARLTSDPT ; DIPVVCLESD ; NGNIMIQKHD ; GITVAVHKMA ; S
Sequence Length
91
Sub Unit
Homodimer. Interacts with SUPV3L1. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently.