ELISA Kit for Mouse Hepatitis A virus cellular receptor 1 homolog

Mfr.No.

E0785m

Alternative Names

Kidney injury molecule 1 ; KIM-1 ; T cell immunoglobulin and mucin domain-containing protein 1 ; TIMD-1 ; T cell membrane protein 1 ; T-cell immunoglobulin mucin receptor 1 ; TIM-1 ; Kim1 ; Tim1 ; Timd1

Categories

Elisa

Function

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.

Specificity

Natural and recombinant Mouse Hepatitis A virus cellular receptor 1 homolog

Subcellular Location

Membrane Single-pass type I membrane protein

Detection Range

0.156-10ng/mL

Entryname

HAVR1_MOUSE

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	89-103%	86-101%	83-99%	97-110%
EDTA plasma(n=5)	97-108%	88-101%	79-102%	89-99%
heparin plasma(n=5)	86-98%	86-99%	94-108%	90-103%

Method Type

Sandwich

Platform

PF07686

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.3%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.8%

Protein Name

Hepatitis A virus cellular receptor 1 homolog

Recovery

Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

Sample Type	Average(%)	Recovery Range (%)
Serum	104	94-110
Plasma	96	89-105

Sensitivity

0.088ng/mL

Sequence

50:

MNQIQVFISG ; LILLLPGAVD ; SYVEVKGVVG ; HPVTLPCTYS ; TYRGITTTCW ;

100:

GRGQCPSSAC ; QNTLIWTNGH ; RVTYQKSSRY ; NLKGHISEGD ; VSLTIENSVE ;

150:

SDSGLYCCRV ; EIPGWFNDQK ; VTFSLQVKPE ; IPTRPPTRPT ; TTRPTATGRP ;

200:

TTISTRSTHV ; PTSIRVSTST ; PPTSTHTWTH ; KPEPTTFCPH ; ETTAEVTGIP ;

250:

SHTPTDWNGT ; VTSSGDTWSN ; HTEAIPPGKP ; QKNPTKGFYV ; GICIAALLLL ;

300:

LLVSTVAITR ; YILMKRKSAS ; LSVVAFRVSK ; IEALQNAAVV ; HSRAEDNIYI ;

305:

VEDRP

Sequence Length

305

String

Q5QNS5

Uniprot	Q5QNS5
Gene Name	Havcr1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:171283
Unigene	Mm.17771

Reference	1. "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family." McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H. Nat. Immunol.2:1109-1116(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS HBA;TISSUE SPECIFICITY strain: BALB/c. tissue: Spleen. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) strain: C57BL/6J. tissue: Blastocyst. 4. "TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation." Meyers J.H., Chakravarti S., Schlesinger D., Illes Z., Waldner H., Umetsu S.E., Kenny J., Zheng X.X., Umetsu D.T., DeKruyff R.H., Strom T.B., Kuchroo V.K. Nat. Immunol.6:455-464(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR TIMD4 5. "Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family." Santiago C., Ballesteros A., Tami C., Martinez-Munoz L., Kaplan G.G., Casasnovas J.M. Immunity26:299-310(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 20-130

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ELISA Kit for Mouse Hepatitis A virus cellular receptor 1 homolog

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