GRB2-associated binder 2 ; Growth factor receptor bound protein 2-associated protein 2 ; PH domain-containing adaptor molecule p97
Categories
Elisa
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Specificity
Natural and recombinant Mouse GRB2-associated-binding protein 2
Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 2-5; 81-91; 251-270; 277-293; 512-529; 630-635 AND 640-648;FUNCTION;PHOSPHORYLATION;INTERACTION WITH GRB2; PTPN11 AND SHC1;TISSUE SPECIFICITY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN11;INTERACTION WITH GRB2; PTPN11 AND PI-3 KINASE
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;INTERACTION WITH TNFRSF11A;PHOSPHORYLATION AT TYR-441
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK;LIPID-BINDING;MUTAGENESIS OF ARG-32
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261; THR-262; TYR-263 AND TYR-290;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-32;PHOSPHORYLATION AT SER-211 AND THR-388
Reviews of ELISA Kit for Mouse GRB2-associated-binding protein 2