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ELISA Kit for Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

SKU : BHE13801745

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2309m
Alternative Names	Core 1 O-glycan T-synthase ; T-syn ; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1 ; 3-galactosyltransferase 1 ; Core 1 beta1 ; 3-galactosyltransferase 1 ; C1GalT1 ; Plt1
Categories	Elisa
Function	Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
Specificity	Natural and recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Subcellular Location	Membrane Single-pass type II membrane protein
Detection Range	0.625-40ng/mL
Entryname	C1GLT_MOUSE
Method Type	Sandwich
Platform	PF02434
Protein Name	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Sensitivity	0.315ng/mL
Sequence	50: MASKSWLNFL ; VFLCGSAIGF ; FLCSQLLSIL ; LREEAAIQPN ; MLHNDPHARH ; 100: SDDNGHSHLK ; GQMNFNADSS ; QHKDENIDVA ; ENLYQKVKIL ; CWVMTSPQNL ; 150: EKKAKHVKAT ; WAQRCNKVLF ; MSSEENQDFP ; TVGLKTKEGR ; EQLYWKTIKA ; 200: FQYVHDHYLE ; DADWFMKADD ; DTYVIVDNLR ; WLLSKYNPEQ ; PIYFGRRFKP ; 250: YVKQGYMSGG ; AGYVLSKEAL ; RRFVNAFKTE ; KCTHSSSIED ; LALGRCMEII ; 300: NVEAGDSRDT ; IGKETFHPFV ; PEHHLIKGYL ; PKTFWYWNYN ; YYPPIEGPGC ; 350: CSDIAVSFHY ; VDGTTMYELE ; YLVYHLRPYG ; YLYRYQPALP ; ENILKEINQV ; 363: NRKEDTKIKL ; GNP
Sequence Length	363
String	Q9JJ06
Sub Unit	Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity.

Uniprot	Q9JJ06
Gene Name	C1galt1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:94192
Unigene	Mm.102752

Reference	1. "Cloning and expression of human core 1 beta1,3-galactosyltransferase." Ju T., Brewer K., D'Souza A., Cummings R.D., Canfield W.M. J. Biol. Chem.277:178-186(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6NCr. strain: FVB/N. tissue: Hematopoietic stem cell. tissue: Kidney. 3. "Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans." Xia L., Ju T., Westmuckett A., An G., Ivanciu L., McDaniel J.M., Lupu F., Cummings R.D., McEver R.P. J. Cell Biol.164:451-459(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY 4. "Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene." Alexander W.S., Viney E.M., Zhang J.-G., Metcalf D., Kauppi M., Hyland C.D., Carpinelli M.R., Stevenson W., Croker B.A., Hilton A.A., Ellis S., Selan C., Nandurkar H.H., Goodnow C.C., Kile B.T., Nicola N.A., Roberts A.W., Hilton D.J. Proc. Natl. Acad. Sci. U.S.A.103:16442-16447(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-321 5. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver.

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