ELISA Kit for Mouse Glutaredoxin-2, mitochondrial

Mfr.No.	E12991m
Alternative Names	Grx2
Categories	Elisa
Function	Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Specificity	Natural and recombinant Mouse Glutaredoxin-2, mitochondrial
Subcellular Location	Isoform 2 Nucleus
Detection Range	0.312-20ng/mL
Entryname	GLRX2_MOUSE
Method Type	Sandwich
Platform	PF00462
Protein Name	Glutaredoxin-2, mitochondrial
Sensitivity	0.168ng/mL
Sequence	50: MSWRRAASVG ; RRLVASGRIL ; AGRRGAAGAA ; GSGMGNSTSS ; FWGKSTTTPV ; 100: NQIQETISNN ; CVVIFSKTSC ; SYCSMAKKIF ; HDMNVNYKAV ; ELDMLEYGNQ ; 150: FQDALHKMTG ; ERTVPRIFVN ; GRFIGGAADT ; HRLHKEGKLL ; PLVHQCYLKK ; 156: KQEERH
Sequence Length	156
String	Q923X4
Sub Unit	Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804095	E12991m	96T	$776		Add to Cart