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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Gamma-secretase-activating protein

SKU : BHE13805087

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2079m
Alternative Names	Protein pigeon homolog ; Pion
Categories	Elisa
Function	Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Specificity	Natural and recombinant Mouse Gamma-secretase-activating protein
Subcellular Location	Golgi apparatus trans-Golgi network
Detection Range	0.156-10ng/mL
Entryname	GSAP_MOUSE
Method Type	Sandwich
Platform	PF14959
Protein Name	Gamma-secretase-activating protein
Sensitivity	0.064ng/mL
Sequence	50: MALRLVTHFD ; VLEDVLPSLL ; TQAATTDEGD ; RAGVLETTYG ; SLRVLNIERN ; 100: GNIIYTYKDN ; KGNAVFGLYD ; CQTRQNEHLY ; TFEKDMQAVS ; CSVNSERTVL ; 150: AASFIQYTTE ; GVKNDLQPGS ; KCLTLLVEIH ; PVNNVKVLKA ; VDSCVWVQFL ; 200: YPQAESHLLP ; QNHLLLISEE ; KYIERFHIQI ; TREDGDRVVI ; RNSSHLPRDR ; 250: LAEDFVWAQW ; DLSEQRLYYI ; ELKESRSILK ; CIQFRADESF ; NLMFEMPLDI ; 300: TLTGLRFKLV ; NFGYDYRQDR ; EKLCNQPSLC ; IFTNHTGSLC ; MCYSPKSDSR ; 350: EEITYSVFYL ; HKGYRKIFTA ; APGSADSQVT ; NGADSQVTDG ; IAFLNLGYFV ; 400: AVYSPGHFLH ; LLNIQHPDLV ; CHSLFLTGNN ; KIAAVLPPSP ; LQSLPGSLVL ; 450: DCYSGKVYRV ; TLDQSYLLRF ; LWNAHLDCER ; MAALHCILSC ; SQDPGFPEEQ ; 500: IIQWISEHVS ; ACHSFDLIQE ; FLIASSYWSV ; YAELDDMGML ; LQYSSVLTWN ; 550: TEIPGIKFTT ; EELPLPLMKV ; YGLKGYWAKL ; NSNLEYIKYT ; KPHLHYHNSV ; 600: VRREWHNLIS ; EERTGKRRST ; MYVRNILENA ; MKVIASMETR ; TLEPRLIPFL ; 650: QEEDRHQRLL ; MGLMVSELRD ; HLLRHLQGVE ; KKKIEQMVLD ; YISKLLDLIW ; 700: CLLETSWRKH ; SMHPLVLHLN ; SHCSAADFEV ; FHLMTRILDA ; ASSLCLPLPP ; 750: GFHSLHTILG ; VHCLPLYSLL ; HYIDNGVLLL ; TETAVTRLMK ; DLDNSEKNEQ ; 800: LKFSIIVRLP ; PLIGQKVCRL ; WDHPMSSNII ; SRNHVARLLK ; NYRKEPRNSM ; 850: IDKSSFPVEF ; LPLNYFIEIL ; MGLESSNQAL ; YGFEGHDNVD ; AEFVEEAALK ; 858: HTTMLLGL
Sequence Length	858
String	Q3TCV3
Sub Unit	Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.

Uniprot	Q3TCV3
Gene Name	Gsap
Kegg	mmu:212167
Unigene	Mm.121705

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805087	E2079m	96T	$776		Add to Cart

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