Gamma-interferon-inducible protein IP-30 ; Lysosomal thiol reductase IP30 ; Gilt ; Ip30
Categories
Elisa
Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T cells or crosspresentation.
Specificity
Natural and recombinant Mouse Gamma-interferon-inducible lysosomal thiol reductase