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ELISA Kit for Mouse Gamma-aminobutyric acid type B receptor subunit 1

SKU : BHE13804533

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2151m
Categories	Elisa
Function	Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Specificity	Natural and recombinant Mouse Gamma-aminobutyric acid type B receptor subunit 1
Subcellular Location	Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane (By similarity). Colocalizes with ATF4 in hippocampal neuron dendritic membranes.
Detection Range	0.312-20ng/mL
Entryname	GABR1_MOUSE
Method Type	Sandwich
Platform	PF00003
Protein Name	Gamma-aminobutyric acid type B receptor subunit 1
Sensitivity	0.172ng/mL
Sequence	50: MLLLLLVPLF ; LRPLGAGGAQ ; TPNVTSEGCQ ; IIHPPWEGGI ; RYRGLTRDQV ; 100: KAINFLPVDY ; EIEYVCRGER ; EVVGPKVRKC ; LANGSWTDMD ; TPSRCVRICS ; 150: KSYLTLENGK ; VFLTGGDLPA ; LDGARVDFRC ; DPDFHLVGSS ; RSICSQGQWS ; 200: TPKPHCQVNR ; TPHSERRAVY ; IGALFPMSGG ; WPGGQACQPA ; VEMALEDVNS ; 250: RRDILPDYEL ; KLIHHDSKCD ; PGQATKYLYE ; LLYNDPIKII ; LMPGCSSVST ; 300: LVAEAARMWN ; LIVLSYGSSS ; PALSNRQRFP ; TFFRTHPSAT ; LHNPTRVKLF ; 350: EKWGWKKIAT ; IQQTTEVFTS ; TLDDLEERVK ; EAGIEITFRQ ; SFFSDPAVPV ; 400: KNLKRQDARI ; IVGLFYETEA ; RKVFCEVYKE ; RLFGKKYVWF ; LIGWYADNWF ; 450: KTYDPSINCT ; VEEMTEAVEG ; HITTEIVMLN ; PANTRSISNM ; TSQEFVEKLT ; 500: KRLKRHPEET ; GGFQEAPLAY ; DAIWALALAL ; NKTSGGGGRS ; GVRLEDFNYN ; 550: NQTITDQIYR ; AMNSSSFEGV ; SGHVVFDASG ; SRMAWTLIEQ ; LQGGSYKKIG ; 600: YYDSTKDDLS ; WSKTDKWIGG ; SPPADQTLVI ; KTFRFLSQKL ; FISVSVLSSL ; 650: GIVLAVVCLS ; FNIYNSHVRY ; IQNSQPNLNN ; LTAVGCSLAL ; AAVFPLGLDG ; 700: YHIGRSQFPF ; VCQARLWLLG ; LGFSLGYGSM ; FTKIWWVHTV ; FTKKEEKKEW ; 750: RKTLEPWKLY ; ATVGLLVGMD ; ILTLAIWQIV ; DPLHRTIETF ; AKEEPKEDID ; 800: VSILPQLEHC ; SSKKMNTWLG ; IFYGYKGLLL ; LLGIFLAYET ; KSVSTEKIND ; 850: HRAVGMAIYN ; VAVLCLITAP ; VTMILSSQQD ; AAFAFASLAI ; VFSSYITLVV ; 900: LFVPKMRRLI ; TRGEWQSEAQ ; DTMKTGSSTN ; NNEEEKSRLL ; EKENRELEKI ; 950: IAEKEERVSE ; LRHQLQSRQQ ; IRSRRHPPTP ; PDPSGGLPRG ; PSEPPDRLSC ; 960: DGSRVHLLYK ;
Sequence Length	960
String	Q9WV18
Sub Unit	Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region (By similarity). Interacts with JAKMIP1.

Uniprot	Q9WV18
Gene Name	Gabbr1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:54393
Unigene	Mm.32191

Reference	1. "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor." Sullivan R., Chateauneuf A., Coulombe N., Kolakowski L.F. Jr., Johnson M.P., Hebert T.E., Ethier N., Belley M., Metters K., Abramovitz M., O'Neill G.P., Ng G.Y.K. J. Pharmacol. Exp. Ther.293:460-467(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);FUNCTION;INTERACTION WITH GABBR2;SUBCELLULAR LOCATION 2. "The murine GABA(B) receptor 1: cDNA cloning, tissue distribution, structure of the Gabbr1 gene, and mapping to chromosome 17." Lamp K., Humeny A., Nikolic Z., Imai K., Adamski J., Schiebel K., Becker C.M. Cytogenet. Cell Genet.92:116-121(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B);TISSUE SPECIFICITY 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1A AND 1B) strain: C57BL/6. tissue: Brain. 5. "Role of heteromer formation in GABAB receptor function." Kuner R., Koehr G., Gruenewald S., Eisenhardt G., Bach A., Kornau H.-C. Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2 6. "Marlin-1, a novel RNA-binding protein associates with GABA receptors." Couve A., Restituito S., Brandon J.M., Charles K.J., Bawagan H., Freeman K.B., Pangalos M.N., Calver A.R., Moss S.J. J. Biol. Chem.279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1

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