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ELISA Kit for Mouse G1/S-specific cyclin-D1

SKU : BHE13812095

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0585m
Antigen	CCND1
Alternative Names	Cyl-1
Categories	Elisa
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Specificity	Natural and recombinant Mouse G1/S-specific cyclin-D1
Subcellular Location	Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Detection Range	0.312-20ng/mL
Entryname	CCND1_MOUSE
Method Type	Sandwich
Platform	PF02984
Protein Name	G1/S-specific cyclin-D1
Sensitivity	0.162ng/mL
Sequence	50: MEHQLLCCEV ; ETIRRAYPDT ; NLLNDRVLRA ; MLKTEETCAP ; SVSYFKCVQK ; 100: EIVPSMRKIV ; ATWMLEVCEE ; QKCEEEVFPL ; AMNYLDRFLS ; LEPLKKSRLQ ; 150: LLGATCMFVA ; SKMKETIPLT ; AEKLCIYTDN ; SIRPEELLQM ; ELLLVNKLKW ; 200: NLAAMTPHDF ; IEHFLSKMPE ; ADENKQTIRK ; HAQTFVALCA ; TDVKFISNPP ; 250: SMVAAGSVVA ; AMQGLNLGSP ; NNFLSCYRTT ; HFLSRVIKCD ; PDCLRACQEQ ; 295: IEALLESSLR ; QAQQNVDPKA ; TEEEGEVEEE ; AGLACTPTDV ; RDVDI
Sequence Length	295
String	P25322
Sub Unit	Interacts with USP2 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with FBXO4.

Uniprot	P25322
Gene Name	Ccnd1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12443
Unigene	Mm.273049

Reference	1. "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J. Cell65:701-713(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Genomic organization of the mouse cyclin D1 gene (Cyl-1)." Smith R., Peters G., Dickson C. Genomics25:85-92(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: 129. tissue: Mammary gland. 4. "Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation." Poon R.Y., Toyoshima H., Hunter T. Mol. Biol. Cell6:1197-1213(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN1B IN THE CCND1-CDK4-CDKN1B COMPLEX 5. "Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex." Lin D.I., Barbash O., Kumar K.G., Weber J.D., Harper J.W., Klein-Szanto A.J., Rustgi A., Fuchs S.Y., Diehl J.A. Mol. Cell24:355-366(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH FBXO4;INTERACTION WITH A UBIQUITIN LIGASE COMPLEX CONTAINING CRYAB;SKP1;CUL1 AND FBXO4;MUTAGENESIS OF THR-286;PHOSPHORYLATION AT THR-286 6. "Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation." Barbash O., Egan E., Pontano L.L., Kosak J., Diehl J.A. Oncogene28:4317-4325(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-269;INTERACTION WITH CDKN1B AND CDK4;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-269 AND THR-286

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812095	E0585m	96T	$776		Add to Cart

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