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ELISA Kit for Mouse Frizzled-8

SKU : BHE13804541

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1714m
Categories	Elisa
Function	Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Specificity	Natural and recombinant Mouse Frizzled-8
Subcellular Location	Membrane Multi-pass membrane protein Golgi apparatus Cell membrane Multi-pass membrane protein Colocalizes with GOPC at the Golgi apparatus.
Detection Range	15.6-1000pg/mL
Entryname	FZD8_MOUSE
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-8
Sensitivity	7.91pg/mL
Sequence	50: MEWGYLLEVT ; SLLAALAVLQ ; RSSGAAAASA ; KELACQEITV ; PLCKGIGYNY ; 100: TYMPNQFNHD ; TQDEAGLEVH ; QFWPLVEIQC ; SPDLKFFLCS ; MYTPICLEDY ; 150: KKPLPPCRSV ; CERAKAGCAP ; LMRQYGFAWP ; DRMRCDRLPE ; QGNPDTLCMD ; 200: YNRTDLTTAA ; PSPPRRLPPP ; PPPGEQPPSG ; SGHSRPPGAR ; PPHRGGSSRG ; 250: SGDAAAAPPS ; RGGKARPPGG ; GAAPCEPGCQ ; CRAPMVSVSS ; ERHPLYNRVK ; 300: TGQIANCALP ; CHNPFFSQDE ; RAFTVFWIGL ; WSVLCFVSTF ; ATVSTFLIDM ; 350: ERFKYPERPI ; IFLSACYLFV ; SVGYLVRLVA ; GHEKVACSGG ; APGAGGAGGA ; 400: GGAAAAGAGA ; AGAGASSPGA ; RGEYEELGAV ; EQHVRYETTG ; PALCTVVFLL ; 450: VYFFGMASSI ; WWVILSLTWF ; LAAGMKWGNE ; AIAGYSQYFH ; LAAWLVPSVK ; 500: SIAVLALSSV ; DGDPVAGICY ; VGNQSLDNLR ; GFVLAPLVIY ; LFIGTMFLLA ; 550: GFVSLFRIRS ; VIKQQGGPTK ; THKLEKLMIR ; LGLFTVLYTV ; PAAVVVACLF ; 600: YEQHNRPRWE ; ATHNCPCLRD ; LQPDQARRPD ; YAVFMLKYFM ; CLVVGITSGV ; 650: WVWSGKTLES ; WRALCTRCCW ; ASKGAAVGAG ; AGGSGPGGSG ; PGPGGGGGHG ; 685: GGGGSLYSDV ; STGLTWRSGT ; ASSVSYPKQM ; PLSQV
Sequence Length	685
String	Q61091
Sub Unit	Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1 (By similarity). Interacts (via the PDZ-binding motif) with GPOC (via its PDZ domain). Interacts with RSPO1 and RSPO3.

Uniprot	Q61091
Gene Name	Fzd8
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14370
Unigene	Mm.184289

Reference	1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J. J. Biol. Chem.271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. 4. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner." Sheldahl L.C., Park M., Malbon C.C., Moon R.T. Curr. Biol.9:695-698(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN BETA-CATENIN SIGNALING 5. "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein." Hsieh J.C., Rattner A., Smallwood P.M., Nathans J. Proc. Natl. Acad. Sci. U.S.A.96:3546-3551(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 6. "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled." Yao R., Maeda T., Takada S., Noda T. Biochem. Biophys. Res. Commun.286:771-778(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GOPC;SUBCELLULAR LOCATION;MUTAGENESIS OF VAL-685 7. "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth." Lu W., Yamamoto V., Ortega B., Baltimore D. Cell119:97-108(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 8. "Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression." Nam J.-S., Turcotte T.J., Smith P.F., Choi S., Yoon J.K. J. Biol. Chem.281:13247-13257(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RSPO1 AND RSPO3;FUNCTION 9. "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains." Dann C.E., Hsieh J.-C., Rattner A., Sharma D., Nathans J., Leahy D.J. Nature412:86-90(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 28-155;DISULFIDE BONDS 10. "Structural basis of Wnt recognition by Frizzled." Janda C.Y., Waghray D., Levin A.M., Thomas C., Garcia K.C. Science337:59-64(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-150 IN COMPLEX WITH XENOPUS WNT8

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