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ELISA Kit for Mouse Frizzled-3

SKU : BHE13805020

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11111m
Categories	Elisa
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.
Specificity	Natural and recombinant Mouse Frizzled-3
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Detection Range	1.56-100ng/mL
Entryname	FZD3_MOUSE
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-3
Sensitivity	0.85ng/mL
Sequence	50: MAVSWIVFDL ; WLLTVFLGQI ; GGHSLFSCEP ; ITLRMCQDLP ; YNTTFMPNLL ; 100: NHYDQQTAAL ; AMEPFHPMVN ; LDCSRDFRPF ; LCALYAPICM ; EYGRVTLPCR ; 150: RLCQRAYSEC ; SKLMEMFGVP ; WPEDMECSRF ; PDCDEPYPRL ; VDLNLVGDPT ; 200: EGAPVAVQRD ; YGFWCPRELK ; IDPDLGYSFL ; HVRDCSPPCP ; NMYFRREELS ; 250: FARYFIGLIS ; IICLSATLFT ; FLTFLIDVTR ; FRYPERPIIF ; YAVCYMMVSL ; 300: IFFIGFLLED ; RVACNASSPA ; QYKASTVTQG ; SHNKACTMLF ; MVLYFFTMAG ; 350: SVWWVILTIT ; WFLAAVPKWG ; SEAIEKKALL ; FHASAWGIPG ; TLTIILLAMN ; 400: KIEGDNISGV ; CFVGLYDVDA ; LRYFVLAPLC ; LYVVVGVSLL ; LAGIISLNRV ; 450: RIEIPLEKEN ; QDKLVKFMIR ; IGVFSILYLV ; PLLVVIGCYF ; YEQAYRGIWE ; 500: TTWIQERCRE ; YHIPCPYQVT ; QMSRPDLILF ; LMKYLMALIV ; GIPSIFWVGS ; 550: KKTCFEWASF ; FHGRRKKEIV ; NESRQVLQEP ; DFAQSLLRDP ; NTPIIRKSRG ; 600: TSTQGTSTHA ; SSTQLAMVDD ; QRSKAGSVHS ; KVSSYHGSLH ; RSRDGRYTPC ; 650: SYRGMEERLP ; HGSMSRLTDH ; SRHSSSHRLN ; EQSRHSSIRD ; LSNNPMTHIT ; 666: HGTSMNRVIE ; EDGTSA
Sequence Length	666
String	Q61086
Sub Unit	Interacts with VANGL2.

Uniprot	Q61086
Gene Name	Fzd3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14365
Unigene	Mm.214687

Reference	1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J. J. Biol. Chem.271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY 2. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner." Sheldahl L.C., Park M., Malbon C.C., Moon R.T. Curr. Biol.9:695-698(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: WNT-MEDIATED PKC ACTIVATION 3. "Characterization of mouse frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes." Hung B.S., Wang X.-Q., Cam G.R., Rothnagel J.A. J. Invest. Dermatol.116:940-946(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 4. "Frizzled-3 is required for the development of major fiber tracts in the rostral CNS." Wang Y., Thekdi N., Smallwood P.M., Macke J.P., Nathans J. J. Neurosci.22:8563-8573(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 5. "Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling." Lyuksyutova A.I., Lu C.C., Milanesio N., King L.A., Gu o N., Wang Y., Nathans J., Tessier-Lavigne M., Zou Y. Science302:1984-1988(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE 6. "Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling." Wang Y., Zhang J., Mori S., Nathans J. J. Neurosci.26:355-364(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 7. "The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells." Wang Y., Guo N., Nathans J. J. Neurosci.26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 8. "Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals." Montcouquiol M., Sans N., Huss D., Kach J., Dickman J.D., Forge A., Rachel R.A., Copeland N.G., Jenkins N.A., Bogani D., Murdoch J., Warchol M.E., Wenthold R.J., Kelley M.W. J. Neurosci.26:5265-5275(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VANGL2 9. "Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development." Armstrong A., Ryu Y.K., Chieco D., Kuruvilla R. J. Neurosci.31:2371-2381(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE 10. "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons." Hua Z.L., Smallwood P.M., Nathans J. Elife2:E01482-E01482(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;CONDITIONAL KNOCKOUTS 11. "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system." Hua Z.L., Jeon S., Caterina M.J., Nathans J. Proc. Natl. Acad. Sci. U.S.A.111:E3005-E3005(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;CONDITIONAL KNOCKOUTS

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