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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Fibroblast growth factor receptor 1

SKU : BHE13804086

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0074m
Alternative Names	Basic fibroblast growth factor receptor 1 ; MFR ; Proto-oncogene c-Fgr ; CD331 ; Flg
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Specificity	Natural and recombinant Mouse Fibroblast growth factor receptor 1
Subcellular Location	Isoform 5 Cell membrane Single-pass type I membrane protein
Detection Range	78-5000pg/mL
Entryname	FGFR1_MOUSE
Method Type	Sandwich
Platform	PF07679
Protein Name	Fibroblast growth factor receptor 1
Sensitivity	40.3pg/mL
Sequence	50: MWGWKCLLFW ; AVLVTATLCT ; ARPAPTLPEQ ; AQPWGVPVEV ; ESLLVHPGDL ; 100: LQLRCRLRDD ; VQSINWLRDG ; VQLVESNRTR ; ITGEEVEVRD ; SIPADSGLYA ; 150: CVTSSPSGSD ; TTYFSVNVSD ; ALPSSEDDDD ; DDDSSSEEKE ; TDNTKPNRRP ; 200: VAPYWTSPEK ; MEKKLHAVPA ; AKTVKFKCPS ; SGTPNPTLRW ; LKNGKEFKPD ; 250: HRIGGYKVRY ; ATWSIIMDSV ; VPSDKGNYTC ; IVENEYGSIN ; HTYQLDVVER ; 300: SPHRPILQAG ; LPANKTVALG ; SNVEFMCKVY ; SDPQPHIQWL ; KHIEVNGSKI ; 350: GPDNLPYVQI ; LKTAGVNTTD ; KEMEVLHLRN ; VSFEDAGEYT ; CLAGNSIGLS ; 400: HHSAWLTVLE ; ALEERPAVMT ; SPLYLEIIIY ; CTGAFLISCM ; LGSVIIYKMK ; 450: SGTKKSDFHS ; QMAVHKLAKS ; IPLRRQVTVS ; ADSSASMNSG ; VLLVRPSRLS ; 500: SSGTPMLAGV ; SEYELPEDPR ; WELPRDRLVL ; GKPLGEGCFG ; QVVLAEAIGL ; 550: DKDKPNRVTK ; VAVKMLKSDA ; TEKDLSDLIS ; EMEMMKMIGK ; HKNIINLLGA ; 600: CTQDGPLYVI ; VEYASKGNLR ; EYLQARRPPG ; LEYCYNPSHN ; PEEQLSSKDL ; 650: VSCAYQVARG ; MEYLASKKCI ; HRDLAARNVL ; VTEDNVMKIA ; DFGLARDIHH ; 700: IDYYKKTTNG ; RLPVKWMAPE ; ALFDRIYTHQ ; SDVWSFGVLL ; WEIFTLGGSP ; 750: YPGVPVEELF ; KLLKEGHRMD ; KPSNCTNELY ; MMMRDCWHAV ; PSQRPTFKQL ; 800: VEDLDRIVAL ; TSNQEYLDLS ; IPLDQYSPSF ; PDTRSSTCSS ; GEDSVFSHEP ; 822: LPEEPCLPRH ; PTQLANSGLK ; RR
Sequence Length	822
String	P16092
Sub Unit	Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2A. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2 (By similarity). Interacts with SOX2 and SOX3.

Uniprot	P16092
Gene Name	Fgfr1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14182
Unigene	Mm.265716

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804086	E0074m	96T	$776		Add to Cart

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