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ELISA Kit for Mouse Eukaryotic translation initiation factor 3 subunit A

SKU : BHE13803624

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1885m
Alternative Names	Centrosomin ; Eukaryotic translation initiation factor 3 subunit 10 ; eIF-3-theta ; eIF3 p167 ; eIF3 p180 ; eIF3 p185 ; p162 ; Csma ; Eif3 ; Eif3s10
Categories	Elisa
Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Specificity	Natural and recombinant Mouse Eukaryotic translation initiation factor 3 subunit A
Subcellular Location	Cytoplasm Cytoplasm cytoskeleton centrosome Nucleus Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus.
Entryname	EIF3A_MOUSE
Platform	PF01399
Protein Name	Eukaryotic translation initiation factor 3 subunit A
Sequence	50: MPAYFQRPEN ; ALKRANEFLE ; VGKKQPALDV ; LYDVMKSKKH ; RTWQKIHEPI ; 100: MLKYLELCVD ; LRKSHLAKEG ; LYQYKNICQQ ; VNIKSLEDVV ; RAYLKLAEEK ; 150: TEAAKEESQQ ; MVLDIEDLDN ; IQTPESVLLS ; AVSGEDTQDR ; TDRLLLTPWV ; 200: KFLWESYRQC ; LDLLRNNSRV ; ERLYHDIAQQ ; AFKFCLQYTR ; KAEFRKLCDN ; 250: LRMHLSQIQR ; HHNQSTAINL ; NNPESQSMHL ; ETRLVQLDSA ; ISMELWQEAF ; 300: KAVEDIHGLF ; SLSKKPPKPQ ; LMANYYNKVS ; TVFWKSGNAL ; FHASTLHRLY ; 350: HLSREMRKNL ; TQEEMQRMST ; RVLLATLSIP ; ITPERTDIAR ; LLDMDGIIVE ; 400: KQRRLATLLG ; LQAPPTRIGL ; INDMVRFSVL ; QYVVPEVKDL ; YNWLEVEFNP ; 450: LKLCERVTKV ; LNWVREQPEK ; EPELQQYVPQ ; LQNNTILRLL ; QQVAQIYQSI ; 500: EFSRLTSLVP ; FVDAFQLERA ; IVDAARHCDL ; QVRIDHTSRT ; LSFGSDLNYA ; 550: TREDAPVGPH ; LQSMPSEQIR ; NQLTAMSSVL ; AKALEVIRPA ; HILQEKEEQH ; 600: QLAVNAYLKN ; SRKEHQRILA ; RRQTIEERKE ; RLESLNIQRE ; KEELEQREAE ; 650: LQKVRKAEEE ; RLRQEAKERE ; KERILQEHEQ ; IKKKTVRERL ; EQIKKTELGA ; 700: KAFKDIDIED ; LEELDPDFIM ; AKQVEQLEKE ; KKELQERLKN ; QEKKIDYFER ; 750: AKRLEEIPLI ; KSAYEEQRVK ; DMDLWEQQEE ; ERITTMQLER ; EKALEHKNRM ; 800: SRMLEDRDLF ; VMRLKAARQS ; VYEEKLKQFE ; ERLAEERHSR ; LEDRKRQRKE ; 850: ERKITYYREK ; EEEEQRRAEE ; QMLKEREERE ; RAERAKREEE ; LREYQERVKK ; 900: LEEVERKKRQ ; RELEIEERER ; RREEERRLGD ; DPLSRKDSRW ; GDRDSEGTWR ; 950: KGPEADSEWR ; RGPPEKEWRR ; ETRDDERPHR ; RDEDRLRRLG ; GDDEERESSL ; 1000: RPDDDRIPRR ; GLDDDRGPRR ; GPDEDRFSRR ; GTDDDRPSWR ; NADDDRPPRR ; 1050: IGDDDRGSWR ; HTDDDRPPRR ; GLDDERGSWR ; TADEDRGPRR ; GMDDDRGPRR ; 1100: GGADDERSSW ; RNADDDRGPR ; RGMDDDRGPR ; RGLDDDRGPW ; RNAAEDRISR ; 1150: RGADDDRGPW ; RNMDDDRVPR ; RGDDARPGPW ; RPFVKPGGWR ; EKEKAREESW ; 1200: GPPRESRPSE ; EREWDRDKEK ; DRDNQDREEN ; DKDLERDRDR ; ERDGDREDRF ; 1250: RRPRDEGGWR ; RGPAEESSSW ; RDSSRRDDRD ; REDRRRDRDD ; RRDLRDLRDR ; 1300: RDLRDDRDRR ; GPPLRSEREE ; ASSWRRTDDR ; KDDRTEERDP ; PRRVPPPALS ; 1344: RDRERERERE ; GEKEKASWRA ; EKDRESLRRT ; KNETDEDGWT ; TVRR
Sequence Length	1344
String	P23116
Sub Unit	Interacts with KRT7 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1 and PIWIL2.

Uniprot	P23116
Gene Name	Eif3a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13669
Unigene	Mm.2238

Reference	1. "Molecular cloning and characterization of the 162 kDa component of a multi-protein complex phosphorylated by Src." Fisher R., Fillmore H., Reynolds A.B. Submitted (1994-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Lymphoma. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing." Petzelt C., Joswig G., Mincheva A., Lichter P., Stammer H., Werner D. J. Cell Sci.110:2573-2578(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 401-1142 (CENTROSOMIN B);SUBCELLULAR LOCATION;RNA EDITING tissue: Ehrlich ascites tumor cell. 4. "Murine cDNAs coding for the centrosomal antigen centrosomin A." Joswig G., Petzelt C., Werner D. J. Cell Sci.98:37-43(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 514-790 (CENTROSOMIN A) tissue: Ehrlich ascites tumor cell. 5. Joswig G., Petzelt C., Werner D. Submitted (1996-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION 6. "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin." Harris T.E., Chi A., Shabanowitz J., Hunt D.F., Rhoads R.E., Lawrence J.C. Jr. EMBO J.25:1659-1668(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3B AND EIF4G1 7. "Reconstitution reveals the functional core of mammalian eIF3." Masutani M., Sonenberg N., Yokoyama S., Imataka H. EMBO J.26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE EIF-3 COMPLEX;IDENTIFICATION IN THE EIF-3 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY 8. "MILI, a PIWI-interacting RNA-binding protein, is required for germ Line stem cell self-renewal and appears to positively regulate translation." Unhavaithaya Y., Hao Y., Beyret E., Yin H., Kuramochi-Miyagawa S., Nakano T., Lin H. J. Biol. Chem.284:6507-6519(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIWIL2

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