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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Epidermal growth factor receptor

SKU : BHE13803960

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0757m
Categories	Elisa
Function	Cell surface receptor for EGF, but also for other members of the EGF family, such as TGF-alpha, BTC/betacellulin, AREGAREGB/amphiregulin, HBEGF, GP30 and vaccinia virus growth factor. Ligand binding triggers a conformation change, leading to activation of the kinase and subsequent phosphorylation of down-stream protein kinases. Is involved in the control of cell growth, proliferation and differentiation.
Specificity	Natural and recombinant Mouse Epidermal growth factor receptor
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Nucleus membrane Single-pass type I membrane protein Endosome In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Co-localizes with TNK2 on the endosomes.
Detection Range	78-5000pg/ml
Entryname	EGFR_MOUSE
Method Type	Sandwich
Platform	PF00757
Protein Name	Epidermal growth factor receptor
Sensitivity	39pg/mL
Sequence	50: MRPSGTARTT ; LLVLLTALCA ; AGGALEEKKV ; CQGTSNRLTQ ; LGTFEDHFLS ; 100: LQRMYNNCEV ; VLGNLEITYV ; QRNYDLSFLK ; TIQEVAGYVL ; IALNTVERIP ; 150: LENLQIIRGN ; ALYENTYALA ; ILSNYGTNRT ; GLRELPMRNL ; QEILIGAVRF ; 200: SNNPILCNMD ; TIQWRDIVQN ; VFMSNMSMDL ; QSHPSSCPKC ; DPSCPNGSCW ; 250: GGGEENCQKL ; TKIICAQQCS ; HRCRGRSPSD ; CCHNQCAAGC ; TGPRESDCLV ; 300: CQKFQDEATC ; KDTCPPLMLY ; NPTTYQMDVN ; PEGKYSFGAT ; CVKKCPRNYV ; 350: VTDHGSCVRA ; CGPDYYEVEE ; DGIRKCKKCD ; GPCRKVCNGI ; GIGEFKDTLS ; 400: INATNIKHFK ; YCTAISGDLH ; ILPVAFKGDS ; FTRTPPLDPR ; ELEILKTVKE ; 450: ITGFLLIQAW ; PDNWTDLHAF ; ENLEIIRGRT ; KQHGQFSLAV ; VGLNITSLGL ; 500: RSLKEISDGD ; VIISGNRNLC ; YANTINWKKL ; FGTPNQKTKI ; MNNRAEKDCK ; 550: AVNHVCNPLC ; SSEGCWGPEP ; RDCVSCQNVS ; RGRECVEKCN ; ILEGEPREFV ; 600: ENSECIQCHP ; ECLPQAMNIT ; CTGRGPDNCI ; QCAHYIDGPH ; CVKTCPAGIM ; 650: GENNTLVWKY ; ADANNVCHLC ; HANCTYGCAG ; PGLQGCEVWP ; SGPKIPSIAT ; 700: GIVGGLLFIV ; VVALGIGLFM ; RRRHIVRKRT ; LRRLLQEREL ; VEPLTPSGEA ; 750: PNQAHLRILK ; ETEFKKIKVL ; GSGAFGTVYK ; GLWIPEGEKV ; KIPVAIKELR ; 800: EATSPKANKE ; ILDEAYVMAS ; VDNPHVCRLL ; GICLTSTVQL ; ITQLMPYGCL ; 850: LDYVREHKDN ; IGSQYLLNWC ; VQIAKGMNYL ; EDRRLVHRDL ; AARNVLVKTP ; 900: QHVKITDFGL ; AKLLGAEEKE ; YHAEGGKVPI ; KWMALESILH ; RIYTHQSDVW ; 950: SYGVTVWELM ; TFGSKPYDGI ; PASDISSILE ; KGERLPQPPI ; CTIDVYMIMV ; 1000: KCWMIDADSR ; PKFRELILEF ; SKMARDPQRY ; LVIQGDERMH ; LPSPTDSNFY ; 1050: RALMDEEDME ; DVVDADEYLI ; PQQGFFNSPS ; TSRTPLLSSL ; SATSNNSTVA ; 1100: CINRNGSCRV ; KEDAFLQRYS ; SDPTGAVTED ; NIDDAFLPVP ; EYVNQSVPKR ; 1150: PAGSVQNPVY ; HNQPLHPAPG ; RDLHYQNPHS ; NAVGNPEYLN ; TAQPTCLSSG ; 1200: FNSPALWIQK ; GSHQMSLDNP ; DYQQDFFPKE ; TKPNGIFKGP ; TAENAEYLRV ; 1210: APPSSEFIGA ;
Sequence Length	1210
String	Q01279
Sub Unit	EGF binding triggers dimerization of the receptor and promotes autophosphorylation. The activate receptor dimer binds one EGF molecule. Heterodimer with ERBB2. Interacts with ERRFI1. Interaction with ERRFI1 inhibits dimerization of the kinase domain and autophosphorylation. Binds RIPK1. Interacts (via autophosphorylated C-terminal tail) with CBL. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts (autophosphorylated form) with PIK3C2B; the interaction may be indirect. Interacts with PELP1. Binds MUC1. Interacts with AP2M1. Interacts with GAB2. Interacts with COPG, upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with FER.

Uniprot	Q01279
Gene Name	Egfr
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13649
Unigene	Mm.420648

Reference	1. "Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene." Avivi A., Skorecki K., Yayon A., Givol D. Oncogene7:1957-1962(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. tissue: Liver. 2. "Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation." Paria B.C., Das S.K., Andrews G.K., Dey S.K. Proc. Natl. Acad. Sci. U.S.A.90:55-59(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. strain: CD-1. tissue: Decidua. tissue: Liver. 3. Hibbs M.L. Submitted (1994-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. tissue: Liver. 4. "The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase." Luetteke N.C., Phillips H.K., Qiu T.H., Copeland N.G., Earp H.S., Jenkins N.A., Lee D.C. Genes Dev.8:399-413(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: B6/C3. tissue: Liver. 5. "Comparison of EGF receptor sequences as a guide to study the ligand binding site." Avivi A., Lax I., Ullrich A., Schlessinger J., Givol D., Morse B. Oncogene6:673-676(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-714 tissue: Brain. 6. Eisinger D.P., Serrero G. Submitted (1992-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 969-1117 strain: C3H. 7. "Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals." Fazioli F., Minichiello L., Matoska V., Castagnino P., Miki T., Wong W.T., di Fiore P.P. EMBO J.12:3799-3808(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL GROWTH;FUNCTION IN PHOSPHORYLATION OF EPS8;INTERACTION WITH EPS8 8. "Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor." Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., Derynck R. Nature376:337-341(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 9. "Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype." Threadgill D.W., Dlugosz A.A., Hansen L.A., Tennenbaum T., Lichti U., Yee D., LaMantia C., Mourton T., Herrup K., Harris R.C. Science269:230-234(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 10. "Strain-dependent epithelial defects in mice lacking the EGF receptor." Sibilia M., Wagner E.F. Science269:234-238(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 11. "Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis." Confalonieri S., Salcini A.E., Puri C., Tacchetti C., Di Fiore P.P. J. Cell Biol.150:905-912(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF EPS15;ENZYME REGULATION;ENDOCYTOSIS 12. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res.5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-352 AND ASN-444 strain: C57BL/6. tissue: Plasma. 13. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res.6:987-995(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 strain: C57BL/6. tissue: Plasma. 14. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver. 15. "The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor." Smith C.J., Berry D.M., McGlade C.J. J. Cell Sci.126:1366-1380(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBQUITINATION BY RNF115 AND RNF126;INTERACTION WITH RNF115 AND RNF126

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