3-keto acyl-CoA synthase Elovl1 ; ELOVL fatty acid elongase 1 ; ELOVL FA elongase 1 ; Very long chain 3-ketoacyl-CoA synthase 1 ; Very long chain 3-oxoacyl-CoA synthase 1 ; Ssc1
Categories
Elisa
Function
Involved in the biosynthesis of C26 fatty acids and sphingolipids. Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Important for sphingolipid biosynthesis.
Specificity
Natural and recombinant Mouse Elongation of very long chain fatty acids protein 1
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein