E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
Specificity
Natural and recombinant Mouse E3 ubiquitin-protein ligase UBR4
Subcellular Location
Membrane Multi-pass membrane protein Cytoplasm Cytoplasm cytoskeleton Nucleus Concentrates at the leading edge of membrane structures involved in actin motility.