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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Cullin-5

SKU : BHE13803336

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15273m
Categories	Elisa
Function	Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Specificity	Natural and recombinant Mouse Cullin-5
Entryname	CUL5_MOUSE
Platform	PF00888
Protein Name	Cullin-5
Sequence	50: MATSNLLKNK ; GSLQFEDKWD ; FMHPIVLKLL ; RQESVTKQQW ; FDLFSDVHAV ; 100: CLWDDKGSSK ; IHQALKEDIL ; EFIKQAQARV ; LSHQDDTALL ; KAYIVEWRKF ; 150: FTQCDILPKP ; FCQLEVTLLG ; KQSSNKKSNM ; EDSIVRKLML ; DTWNESIFSN ; 200: IKNRLQDSAM ; KLVHAERLGE ; AFDSQLVIGV ; RESYVNLCSN ; PEDKLQIYRD ; 250: NFEKAYLDST ; ERFYRTQAPS ; YLQQNGVQNY ; MKYADAKLKE ; EEKRALRYLE ; 300: TRRECNSVEA ; LMECCVNALV ; TSFKETILAE ; CQGMIKRNET ; EKLHLMFSLM ; 350: DKVPNGIEPM ; LKDLEEHIIS ; AGLADMVAAA ; ETITTDSEKY ; VEQLLTLFNR ; 400: FSKLVKEAFQ ; DDPRFLTARD ; KAYKAVVNDA ; TIFKLELPLK ; QKGVGLKTQP ; 450: ESKCPELLAN ; YCDMLLRKTP ; LSKKLTSEEI ; EAKLKEVLLV ; LKYVQNKDVF ; 500: MRYHKAHLTR ; RLILDISADS ; EIEENMVEWL ; REVGMPADYV ; NKLARMFQDI ; 550: KVSEDLNQAF ; KEMHKNNKLA ; LPADSVNIKI ; LNAGAWSRSS ; EKVFVSLPTE ; 600: LEDLIPEVEE ; FYKKNHSGRK ; LHWHHLMSNG ; IITFKNEVGQ ; YDLEVTTFQL ; 650: AVLFAWNQRP ; REKISFENLK ; LATELPDAEL ; RRTLWSLVAF ; PKLKRQVLLY ; 700: DPQVNSPKDF ; TEGTLFSVNQ ; DFSLIKNAKV ; QKRGKINLIG ; RLQLTTERMR ; 750: EEENEGIVQL ; RILRTQEAII ; QIMKMRKKIS ; NAQLQTELVE ; ILKNMFLPQK ; 780: KMIKEQMEWL ; IEHRYIRRDE ; ADINTFIYMA ;
Sequence Length	780
String	Q9D5V5
Sub Unit	Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, the Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.

Uniprot	Q9D5V5
Gene Name	Cul5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:75717
Unigene	Mm.218910

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803336	E15273m	96T	$776		Add to Cart

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