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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Caspase-9

SKU : BHE13801584

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0627m
Alternative Names	Apoptotic protease Mch-6 ; Apoptotic protease-activating factor 3 ; APAF-3 ; ICE-like apoptotic protease 6 ; ICE-LAP6 ; Mch6
Categories	Elisa
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Specificity	Natural and recombinant Mouse Caspase-9
Entryname	CASP9_MOUSE
Platform	PF00619
Protein Name	Caspase-9
Sequence	50: MDEADRQLLR ; RCRVRLVSEL ; QVAELWDALL ; SRELFTRDMI ; EDIQQAGSGS ; 100: RRDQARQLVT ; DLETRGRQAL ; PLFISCLEDT ; GQGTLASLLQ ; SGRQAAKQDP ; 150: EAVKPLDHLV ; PVVLGPMGLT ; AKEQRVVKLD ; PSQPAVGNLT ; PVVLGPEELW ; 200: PARLKPEVLR ; PETPRPVDIG ; SGGAHDVCVP ; GKIRGHADMA ; YTLDSDPCGH ; 250: CLIINNVNFC ; PSSGLGTRTG ; SNLDRDKLEH ; RFRWLRFMVE ; VKNDLTAKKM ; 300: VTALMEMAHR ; NHRALDCFVV ; VILSHGCQAS ; HLQFPGAVYG ; TDGCSVSIEK ; 350: IVNIFNGSGC ; PSLGGKPKLF ; FIQACGGEQK ; DHGFEVACTS ; SQGRTLDSDS ; 400: EPDAVPYQEG ; PRPLDQLDAV ; SSLPTPSDIL ; VSYSTFPGFV ; SWRDKKSGSW ; 450: YIETLDGILE ; QWARSEDLQS ; LLLRVANAVS ; AKGTYKQIPG ; CFNFLRKKLF ; 454: FKTS
Sequence Length	454
Sub Unit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts (inactive form) with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin. Interacts with ABL1 (via SH3 domain); the interaction is direct and increased in the response of cells to genotoxic stress and ABL1/c-Abl activation.

Uniprot	Q8C3Q9
Gene Name	Casp9
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12371
Unigene	Mm.88829

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801584	E0627m	96T	$776		Add to Cart

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