ELISA Kit for Mouse Carbonyl reductase [NADPH] 1

Mfr.No.	E10192m
Alternative Names	15-hydroxyprostaglandin dehydrogenase [NADP(+)] ; 1.1.1.197 ; NADPH-dependent carbonyl reductase 1 ; Prostaglandin 9-ketoreductase ; Prostaglandin-E(2) 9-reductase ; 1.1.1.189 ; Cbr
Categories	Elisa
Function	NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Specificity	Natural and recombinant Mouse Carbonyl reductase [NADPH] 1
Subcellular Location	Cytoplasm
Entryname	CBR1_MOUSE
Platform	PF00106
Protein Name	Carbonyl reductase [NADPH] 1
Sequence	50: MSSSRPVALV ; TGANKGIGFA ; ITRDLCRKFS ; GDVVLAARDE ; ERGQTAVQKL ; 100: QAEGLSPRFH ; QLDIDNPQSI ; RALRDFLLKE ; YGGLDVLVNN ; AGIAFKVNDD ; 150: TPFHIQAEVT ; MKTNFFGTRD ; VCKELLPLIK ; PQGRVVNVSS ; MVSLRALKNC ; 200: RLELQQKFRS ; ETITEEELVG ; LMNKFVEDTK ; KGVHAEEGWP ; NSAYGVTKIG ; 250: VTVLSRILAR ; KLNEQRRGDK ; ILLNACCPGW ; VRTDMAGPKA ; TKSPEEGAET ; 277: PVYLALLPPD ; AEGPHGQFVQ ; DKKVEPW
Sequence Length	277
String	P48758
Sub Unit	Monomer.

Reference	1. "Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11." Wei J., Dlouhy S.R., Hara A., Ghetti B., Hodes M.E. Genomics34:147-148(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: CBA/CJ. tissue: Cerebellum. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Colon. 3. Lubec G., Klug S., Sunyer B., Chen W.-Q. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-71; 80-96 AND 221-232;IDENTIFICATION BY MASS SPECTROMETRY strain: OF1. tissue: Hippocampus.

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BHE13801961	E10192m	96T	$776		Add to Cart