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ELISA Kit for Mouse Cadherin-5

SKU : BHE13801512

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1366m
Alternative Names	Vascular endothelial cadherin ; VE-cadherin ; CD144
Categories	Elisa
Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Specificity	Natural and recombinant Mouse Cadherin-5
Subcellular Location	Cell junction Cell membrane Single-pass type I membrane protein Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Detection Range	0.312-20ng/mL
Entryname	CADH5_MOUSE
Method Type	Sandwich
Platform	PF00028
Protein Name	Cadherin-5
Sensitivity	0.16ng/mL
Sequence	50: MQRLTELATA ; LGAFLGLLAV ; AAMAGPNFPQ ; IDTPNMLPAH ; HRQKRDWIWN ; 100: QMHIDEEKNE ; SLPHYVGKIK ; SNVNRQNAKY ; VLQGEFAGKI ; FGVDANTGNV ; 150: LAYERLDREK ; VSEYFLTALI ; VDKNTNKNLE ; QPSSFTVKVH ; DINDNWPVFS ; 200: HQVFNASVPE ; MSAIGTSVIR ; VTAVDADDPT ; VAGHATVLYQ ; IVKGNEYFSI ; 250: DNSGLIFTKI ; KNLDREKQAE ; YKIVVETQDA ; LGLRGESGTA ; TVMIRLEDIN ; 300: DNFPVFTQST ; YTFSVPEDIR ; VGKPLGFLTV ; VDPDEPQNRM ; TKYSIMQGEY ; 350: RDTFTIETDP ; KRNEGIIKPT ; KSLDYEVIQQ ; YTFYIEATDP ; TIRYEYLSST ; 400: SGKNKAMVTI ; NVLDVDEPPV ; FQRHFYHFKL ; PENQKKPLIG ; TVVAKDPDKA ; 450: QRSIGYSIRK ; TSDRGQFFRI ; TKQGNIYNEK ; ELDRETYAWY ; NLTVEANELD ; 500: SRGNPVGKES ; IVQVYIEVLD ; ENDNPPEFAQ ; PYEPKVCENA ; AQGKLVVQIS ; 550: ATDKDVVPVN ; PKFKFALKNE ; DSNFTLINNH ; DNTANITVKY ; GQFNREHAKF ; 600: HYLPVLISDN ; GVPSLTGTST ; LTVGVCKCNE ; QGEFTFCEEM ; AAQAGVSIQA ; 650: LVAIFLCILT ; ITVITLLIIL ; RRRIRKQAHA ; HSKSALEIHE ; QLVTYDEEGG ; 700: GEMDTTSYDV ; SVLNSVRGGS ; TKPLRSTMDA ; RPAVYTQVQK ; PPRLAPGLHG ; 750: GPREMATMID ; VKKEEADNDG ; GGPPYDTLHI ; YGYEGAESIA ; ESLSSLSTNS ; 784: SDSDIDYDFL ; NDWGPRFKML ; AELYGSDPQE ; ELII
Sequence Length	784
String	P55284
Sub Unit	Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1.

Uniprot	P55284
Gene Name	Cdh5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12562
Unigene	Mm.21767

Reference	1. "Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system." Breier G., Breviario F., Caveda L., Berthier R., Schnuerch H., Gotsch U., Vestweber D., Risau W., Dejana E. Blood87:630-641(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain capillary. 2. Breviario F. Submitted (2003-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 67-70 3. "In vivo evidence of the critical role of cadherin-5 in murine vascular integrity." Matsuyoshi N., Toda K., Horiguchi Y., Tanaka T., Nakagawa S., Takeichi M., Imamura S. Proc. Assoc. Am. Physicians109:362-371(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION strain: BALB/c. tissue: Mammary carcinoma. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6. tissue: Brain. 5. "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts." Nawroth R., Poell G., Ranft A., Kloep S., Samulowitz U., Fachinger G., Golding M., Shima D.T., Deutsch U., Vestweber D. EMBO J.21:4885-4895(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRB;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRB 6. Nawroth R., Poell G., Ranft A., Kloep S., Samulowitz U., Fachinger G., Golding M., Shima D.T., Deutsch U., Vestweber D. EMBO J.24:3158-3158(2005) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM 7. "Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1." Kanemura H., Satoh T., Bilasy S.E., Ueda S., Hirashima M., Kataoka T. Biochem. Biophys. Res. Commun.387:754-759(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE 8. "CCM1 regulates vascular-lumen organization by inducing endothelial polarity." Lampugnani M.G., Orsenigo F., Rudini N., Maddaluno L., Boulday G., Chapon F., Dejana E. J. Cell Sci.123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 9. "SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development." Costa G., Mazan A., Gandillet A., Pearson S., Lacaud G., Kouskoff V. Development139:1587-1598(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;DEVELOPMENTAL STAGE 10. "Distal interactions within the par3-VE-cadherin complex." Tyler R.C., Peterson F.C., Volkman B.F. Biochemistry49:951-957(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 769-784 IN COMPLEX WITH PARD3;INTERACTION WITH PARD3;MUTAGENESIS OF TYR-774 AND ASP-777

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