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ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

SKU : BHE13806218

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1916m
Alternative Names	Histone arginine demethylase JMJD6 ; JmjC domain-containing protein 6 ; Jumonji domain-containing protein 6 ; Lysyl-hydroxylase JMJD6 ; Peptide-lysine 5-dioxygenase JMJD6 ; Phosphatidylserine receptor ; Protein PTDSR ; Kiaa0585 ; Ptdsr
Categories	Elisa
Function	Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
Specificity	Natural and recombinant Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Subcellular Location	Nucleus nucleoplasm Nucleus nucleolus Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Detection Range	0.78-50ng/mL
Entryname	JMJD6_MOUSE
Method Type	Sandwich
Platform	PF02373
Protein Name	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Sensitivity	0.399ng/mL
Sequence	50: MNHKSKKRIR ; EAKRSARPEL ; KDSLDWTRHN ; YYESYPLNPA ; AVPDNVERAD ; 100: ALQLSVKEFV ; ERYERPYKPV ; VLLNAQEGWS ; AQEKWTLERL ; KRKYRNQKFK ; 150: CGEDNDGYSV ; KMKMKYYIEY ; MESTRDDSPL ; YIFDSSYGEH ; PKRRKLLEDY ; 200: KVPKFFTDDL ; FQYAGEKRRP ; PYRWFVMGPP ; RSGTGIHIDP ; LGTSAWNALV ; 250: QGHKRWCLFP ; TNTPRELIKV ; TREEGGNQQD ; EAITWFNVIY ; PRTQLPTWPP ; 300: EFKPLEILQK ; PGETVFVPGG ; WWHVVLNLDT ; TIAITQNFAS ; STNFPVVWHK ; 350: TVRGRPKLSR ; KWYRILKQEH ; PELAVLADAV ; DLQESTGIAS ; DSSSDSSSSS ; 400: SSSSSDSDSE ; CESGSEGDGT ; THRRKKRRTC ; SMVGNGDTTS ; QDDCVSKERS ; 403: SSR
Sequence Length	403
String	Q9ERI5
Sub Unit	Interacts with LUC7L2 and LUC7L3 (By similarity). Interacts with U2AF2/U2AF65.

Uniprot	Q9ERI5
Gene Name	Jmjd6
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:107817
Unigene	Mm.481684

Reference	1. "A receptor for phosphatidylserine-specific clearance of apoptotic cells." Fadok V.A., Bratton D.L., Rose D.M., Pearson A., Ezekewitz R.A., Henson P.M. Nature405:85-90(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: Swiss Webster. tissue: Brain. 2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) tissue: Brain. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) strain: 129. tissue: Mammary tumor. 5. "Phosphatidylserine receptor is required for clearance of apoptotic cells." Li M.O., Sarkisian M.R., Mehal W.Z., Rakic P., Flavell R.A. Science302:1560-1563(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 6. "Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor." Kunisaki Y., Masuko S., Noda M., Inayoshi A., Sanui T., Harada M., Sasazuki T., Fukui Y. Blood103:3362-3364(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 7. "Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals." Cui P., Qin B., Liu N., Pan G., Pei D. Exp. Cell Res.293:154-163(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION 8. "The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal." Boese J., Gruber A.D., Helming L., Schiebe S., Wegener I., Hafner M., Beales M., Koentgen F., Lengeling A. J. Biol.3:15.1-15.18(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 9. "Hide and seek: the secret identity of the phosphatidylserine receptor." Williamson P., Schlegel R.A. J. Biol.3:14.1-14.4(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION 10. "Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1." Boeckel J.N., Guarani V., Koyanagi M., Roexe T., Lengeling A., Schermuly R.T., Gellert P., Braun T., Zeiher A., Dimmeler S. Proc. Natl. Acad. Sci. U.S.A.108:3276-3281(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH U2AF2

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