Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.
Specificity
Natural and recombinant Mouse BH3-interacting domain death agonist
Subcellular Location
Cytoplasm Mitochondrion membrane When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane.