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ELISA Kit for Mouse Betatrophin

SKU : BHE13801417

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11644m
Alternative Names	Angiopoietin-like protein 8 ; Lipasin ; Refeeding-induced fat and liver protein ; Angptl8 ; Rifl
Categories	Elisa
Function	Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
Specificity	Natural and recombinant Mouse Betatrophin
Subcellular Location	Secreted
Detection Range	0.156-10ng/mL
Entryname	BETAT_MOUSE
Method Type	Sandwich
Protein Name	Betatrophin
Sensitivity	0.081ng/mL
Sequence	50: MAVLALCLLW ; TLASAVRPAP ; VAPLGGPEPA ; QYEELTLLFH ; GALQLGQALN ; 100: GVYRATEARL ; TEAGHSLGLY ; DRALEFLGTE ; VRQGQDATQE ; LRTSLSEIQV ; 150: EEDALHLRAE ; ATARSLGEVA ; RAQQALRDTV ; RRLQVQLRGA ; WLGQAHQEFE ; 198: TLKARADKQS ; HLLWALTGHV ; QRQQREMAEQ ; QQWLRQIQQR ; LHTAALPA
Sequence Length	198
Sub Unit	Interacts with ANGPTL3.

Uniprot	Q8R1L8
Gene Name	Gm6484
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:624219
Unigene	Mm.440264

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-181 strain: FVB/N. tissue: Liver. 3. "A mouse knockout library for secreted and transmembrane proteins." Tang T., Li L., Tang J., Li Y., Lin W.Y., Martin F., Grant D., Solloway M., Parker L., Ye W., Forrest W., Ghilardi N., Oravecz T., Platt K.A., Rice D.S., Hansen G.M., Abuin A., Eberhart D.E., Godowski P., Holt K.H., Peterson A., Zambrowicz B.P., de Sauvage F.J.more... Nat. Biotechnol.28:749-755(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 4. "Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism." Ren G., Kim J.Y., Smas C.M. Am. J. Physiol.303:E334-E351(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 5. "Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels." Zhang R. Biochem. Biophys. Res. Commun.424:786-792(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION 6. "Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family." Fu Z., Yao F., Abou-Samra A.B., Zhang R. Biochem. Biophys. Res. Commun.430:1126-1131(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION 7. "Atypical angiopoietin-like protein that regulates ANGPTL3." Quagliarini F., Wang Y., Kozlitina J., Grishin N.V., Hyde R., Boerwinkle E., Valenzuela D.M., Murphy A.J., Cohen J.C., Hobbs H.H. Proc. Natl. Acad. Sci. U.S.A.109:19751-19756(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION 8. "Betatrophin: a hormone that controls pancreatic beta cell proliferation." Yi P., Park J.S., Melton D.A. Cell153:747-758(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY 9. "Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis." Wang Y., Quagliarini F., Gusarova V., Gromada J., Valenzuela D.M., Cohen J.C., Hobbs H.H. Proc. Natl. Acad. Sci. U.S.A.110:16109-16114(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE 10. "Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting." Jiao Y., Le Lay J., Yu M., Naji A., Kaestner K.H. Diabetes63:1283-1288(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EXPRESSION IN HUMAN PANCREATIC BETA-CELLS 11. "Perspectives on the activities of ANGPTL8/betatrophin." Yi P., Park J.S., Melton D.A. Cell159:467-468(2014) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN PANCREATIC BETA-CELLS PROLIFERATION 12. "ANGPTL8/betatrophin does not control pancreatic beta cell expansion." Gusarova V., Alexa C.A., Na A., Stevis P.E., Xin Y., Bonner-Weir S., Cohen J.C., Hobbs H.H., Murphy A.J., Yancopoulos G.D., Gromada J. Cell159:691-696(2014) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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