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ELISA Kit for Mouse Bcl2-associated agonist of cell death

SKU : BHE13801540

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15040m
Alternative Names	Bcl-2-binding component 6 ; Bcl-xL/Bcl-2-associated death promoter ; Bcl2 antagonist of cell death ; Bbc6
Categories	Elisa
Function	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Specificity	Natural and recombinant Mouse Bcl2-associated agonist of cell death
Subcellular Location	Mitochondrion outer membrane Cytoplasm Upon phosphorylation, locates to the cytoplasm.
Entryname	BAD_MOUSE
Method Type	Sandwich
Platform	PF10514
Protein Name	Bcl2-associated agonist of cell death
Sequence	50: MGTPKQPSLA ; PAHALGLRKS ; DPGIRSLGSD ; AGGRRWRPAA ; QSMFQIPEFE ; 100: PSEQEDASAT ; DRGLGPSLTE ; DQPGPYLAPG ; LLGSNIHQQG ; RAATNSHHGG ; 150: AGAMETRSRH ; SSYPAGTEED ; EGMEEELSPF ; RGRSRSAPPN ; LWAAQRYGRE ; 200: LRRMSDEFEG ; SFKGLPRPKS ; AGTATQMRQS ; AGWTRIIQSW ; WDRNLGKGGS ; 204: TPSQ
Sequence Length	204
String	Q61337
Sub Unit	Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-112/Ser-136 phosphorylated form binds 14-3-3 proteins. Interacts with PIM3.

Uniprot	Q61337
Gene Name	Bad
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12015
Unigene	Mm.4387

Reference	1. "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death." Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J. Cell80:285-291(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. tissue: Thymus. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: NMRI. tissue: Mammary gland. 3. "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt." Del Peso L., Gonzalez-Garcia M., Page C., Herrera R., Nunez G. Science278:687-689(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136;MUTAGENESIS OF SER-112 AND SER-136 4. "Rsk1 mediates a MEK-MAP kinase cell survival signal." Shimamura A., Ballif B.A., Richards S.A., Blenis J. Curr. Biol.10:127-135(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136 5. "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation." Datta S.R., Katsov A., Hu L., Petros A., Fesik S.W., Yaffe M.B., Greenberg M.E. Mol. Cell6:41-51(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SERINE RESIDUES 6. "p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis." Schurmann A., Mooney A.F., Sanders L.C., Sells M.A., Wang H.G., Reed J.C., Bokoch G.M. Mol. Cell. Biol.20:453-461(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136 7. "p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts." Jakobi R., Moertl E., Koeppel M.A. J. Biol. Chem.276:16624-16634(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 8. "Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD." Villalba M., Bushway P., Altman A. J. Immunol.166:5955-5963(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-136 9. "p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD." Harada H., Andersen J.S., Mann M., Terada N., Korsmeyer S.J. Proc. Natl. Acad. Sci. U.S.A.98:9666-9670(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-136 10. "Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity." Dramsi S., Scheid M.P., Maiti A., Hojabrpour P., Chen X., Schubert K., Goodlett D.R., Aebersold R., Duronio V. J. Biol. Chem.277:6399-6405(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-155 AND SER-170;MUTAGENESIS OF SER-112; SER-155 AND SER-170;IDENTIFICATION BY MASS SPECTROMETRY 11. "The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death." Yan B., Zemskova M., Holder S., Chin V., Kraft A., Koskinen P.J., Lilly M. J. Biol. Chem.278:45358-45367(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 BY PIM2 12. "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association." Jin S., Zhuo Y., Guo W., Field J. J. Biol. Chem.280:24698-24705(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 BY RAF1 13. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver.

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