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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Atypical chemokine receptor 2

SKU : BHE13800447

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14064m
Alternative Names	C-C chemokine receptor D6 ; Chemokine-binding protein 2 ; Chemokine-binding protein D6 ; Ccbp2 ; D6
Categories	Elisa
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Specificity	Natural and recombinant Mouse Atypical chemokine receptor 2
Subcellular Location	Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Entryname	ACKR2_MOUSE
Platform	PF00001
Protein Name	Atypical chemokine receptor 2
Sequence	50: MPTVASPLPL ; TTVGSENSSS ; IYDYDYLDDM ; TILVCRKDEV ; LSFGRVFLPV ; 100: VYSLIFVLGL ; AGNLLLLVVL ; LHSAPRRRTM ; ELYLLNLAVS ; NLLFVVTMPF ; 150: WAISVAWHWV ; FGSFLCKVIS ; TLYSINFYCG ; IFFITCMSLD ; KYLEIVHAQP ; 200: LHRPKAQFRN ; LLLIVMVWIT ; SLAISVPEMV ; FVQIHQTLDG ; VWHCYADFGG ; 250: HATIWKLYLR ; FQLNLLGFLL ; PLLAMIFFYS ; RIGCVLVRLR ; PPGQGRALRM ; 300: AAALVIVFFM ; LWFPYNLTLF ; LHSLLDLHVF ; GNCEISHRLD ; YTLQVTESLA ; 350: FSHCCFTPVL ; YAFCSHRFRR ; YLKAFLSVML ; RWHQAPGTPS ; SNHSESSRVT ; 378: AQEDVVSMND ; LGERQSEDSL ; NKGEMGNT
Sequence Length	378

Uniprot	O08707
Gene Name	Ackr2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:59289
Unigene	Mm.258105

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800447	E14064m	96T	$776		Add to Cart

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