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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Asporin

SKU : BHE13801341

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1043m
Alternative Names	Periodontal ligament-associated protein 1 ; PLAP-1
Categories	Elisa
Function	Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to the BMP receptor-IB (BMPR-IB), resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.
Specificity	Natural and recombinant Mouse Asporin
Subcellular Location	Secreted extracellular space extracellular matrix
Detection Range	1.56-100ng/mL
Entryname	ASPN_MOUSE
Method Type	Sandwich
Platform	PF00560
Protein Name	Asporin
Sensitivity	0.802ng/mL
Sequence	50: MKEYVMLLLL ; AVCSAKPFFS ; PSHTALKNMM ; LKDMEDTDDD ; DNDDDDNSLF ; 100: PTKEPVNPFF ; PFDLFPTCPF ; GCQCYSRVVH ; CSDLGLTSVP ; NNIPFDTRMV ; 150: DLQNNKIKEI ; KENDFKGLTS ; LYALILNNNK ; LTKIHPKTFL ; TTKKLRRLYL ; 200: SHNQLSEIPL ; NLPKSLAELR ; IHDNKVKKIQ ; KDTFKGMNAL ; HVLEMSANPL ; 250: ENNGIEPGAF ; EGVTVFHIRI ; AEAKLTSIPK ; GLPPTLLELH ; LDFNKISTVE ; 300: LEDLKRYREL ; QRLGLGNNRI ; TDIENGTFAN ; IPRVREIHLE ; HNKLKKIPSG ; 350: LQELKYLQII ; FLHYNSIAKV ; GVNDFCPTVP ; KMKKSLYSAI ; SLFNNPMKYW ; 373: EIQPATFRCV ; LGRMSVQLGN ; VGK
Sequence Length	373
String	Q99MQ4
Sub Unit	Interacts with type I collagen. DCN can inhibit collagen binding (By similarity). Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen.

Uniprot	Q99MQ4
Gene Name	Aspn
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:66695
Unigene	Mm.383216

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801341	E1043m	96T	$776		Add to Cart

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