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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Apoptosis regulator Bcl-2

SKU : BHE13801848

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0778m
Alternative Names	Bcl-2
Categories	Elisa
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Specificity	Natural and recombinant Mouse Apoptosis regulator Bcl-2
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	BCL2_MOUSE
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator Bcl-2
Sensitivity	0.087ng/mL
Sequence	50: MAQAGRTGYD ; NREIVMKYIH ; YKLSQRGYEW ; DAGDADAAPL ; GAAPTPGIFS ; 100: FQPESNPMPA ; VHREMAARTS ; PLRPLVATAG ; PALSPVPPCV ; HLTLRRAGDD ; 150: FSRRYRRDFA ; EMSSQLHLTP ; FTARGRFATV ; VEELFRDGVN ; WGRIVAFFEF ; 200: GGVMCVESVN ; REMSPLVDNI ; ALWMTEYLNR ; HLHTWIQDNG ; GWDAFVELYG ; 236: PSMRPLFDFS ; WLSLKTLLSL ; ALVGACITLG ; AYLGHK
Sequence Length	236
String	P10417
Sub Unit	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, MRPL41, RAF-1 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner.

Uniprot	P10417
Gene Name	Bcl2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12043
Unigene	Mm.257460

Reference	1. "Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma." Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M. Cell49:455-463(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA AND BETA) strain: BALB/c. tissue: Liver. 2. "Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo." Eguchi Y., Ewert D.L., Tsujimoto Y. Nucleic Acids Res.20:4187-4192(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 221-222 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Olfactory epithelium. 6. "Bcl-2 phosphorylation required for anti-apoptosis function." Ito T., Deng X., Carr B., May W.S. Jr. J. Biol. Chem.272:11671-11673(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-70 BY PKC;MUTAGENESIS OF SER-70 7. "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A." Deng X., Ito T., Carr B., Mumby M., May W.S. Jr. J. Biol. Chem.273:34157-34163(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION BY PP2A 8. "Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness." Zhao X., Ayer R.E., Davis S.L., Ames S.J., Florence B., Torchinsky C., Liou J.S., Shen L., Spanjaard R.A. Cancer Res.65:2125-2129(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EI24

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801848	E0778m	96T	$776		Add to Cart

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