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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Apoptosis regulator BAX

SKU : BHE13801037

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1343m
Categories	Elisa
Function	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.
Specificity	Natural and recombinant Mouse Apoptosis regulator BAX
Subcellular Location	Isoform Gamma Cytoplasm
Detection Range	31.2-2000pg/mL
Entryname	BAX_MOUSE
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator BAX
Sensitivity	15.6pg/mL
Sequence	50: MDGSGEQLGS ; GGPTSSEQIM ; KTGAFLLQGF ; IQDRAGRMAG ; ETPELTLEQP ; 100: PQDASTKKLS ; ECLRRIGDEL ; DSNMELQRMI ; ADVDTDSPRE ; VFFRVAADMF ; 150: ADGNFNWGRV ; VALFYFASKL ; VLKALCTKVP ; ELIRTIMGWT ; LDFLRERLLV ; 192: WIQDQGGWEG ; LLSYFGTPTW ; QTVTIFVAGV ; LTASLTIWKK ; MG
Sequence Length	192
String	Q07813
Sub Unit	Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells.

Uniprot	Q07813
Gene Name	Bax
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12028
Unigene	Mm.19904

Reference	1. "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Cell74:609-619(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH BCL2;FUNCTION strain: C57BL/6 X DBA/2. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N-3. tissue: Mammary tumor. 3. "Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX." Ku B., Liang C., Jung J.U., Oh B.H. Cell Res.21:627-641(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 52-82 IN COMPLEX WITH BCL2;FUNCTION;INTERACTION WITH BCL2 AND BCL2L2

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801037	E1343m	96T	$776		Add to Cart

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