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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Amyloid beta A4 protein

SKU : BHE13800183

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0946m
Alternative Names	ABPP ; APP ; Alzheimer disease amyloid A4 protein homolog ; Amyloid precursor protein ; Amyloidogenic glycoprotein ; AG ; Beta-amyloid precursor protein
Categories	Elisa
Function	N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Specificity	Natural and recombinant Mouse Amyloid beta A4 protein
Subcellular Location	Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FPRL1 at the cell surface and the complex is then rapidly internalized (By similarity). APP sorts to the basolateral surface in epithelial cells (By similarity). During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment.
Detection Range	78-5000pg/mL
Entryname	A4_MOUSE
Method Type	Sandwich
Platform	PF10515
Protein Name	Amyloid beta A4 protein
Sensitivity	39pg/mL
Sequence	50: MLPSLALLLL ; AAWTVRALEV ; PTDGNAGLLA ; EPQIAMFCGK ; LNMHMNVQNG ; 100: KWESDPSGTK ; TCIGTKEGIL ; QYCQEVYPEL ; QITNVVEANQ ; PVTIQNWCKR ; 150: GRKQCKTHTH ; IVIPYRCLVG ; EFVSDALLVP ; DKCKFLHQER ; MDVCETHLHW ; 200: HTVAKETCSE ; KSTNLHDYGM ; LLPCGIDKFR ; GVEFVCCPLA ; EESDSVDSAD ; 250: AEEDDSDVWW ; GGADTDYADG ; GEDKVVEVAE ; EEEVADVEEE ; EADDDEDVED ; 300: GDEVEEEAEE ; PYEEATERTT ; STATTTTTTT ; ESVEEVVREV ; CSEQAETGPC ; 350: RAMISRWYFD ; VTEGKCVPFF ; YGGCGGNRNN ; FDTEEYCMAV ; CGSVSTQSLL ; 400: KTTSEPLPQD ; PDKLPTTAAS ; TPDAVDKYLE ; TPGDENEHAH ; FQKAKERLEA ; 450: KHRERMSQVM ; REWEEAERQA ; KNLPKADKKA ; VIQHFQEKVE ; SLEQEAANER ; 500: QQLVETHMAR ; VEAMLNDRRR ; LALENYITAL ; QAVPPRPHHV ; FNMLKKYVRA ; 550: EQKDRQHTLK ; HFEHVRMVDP ; KKAAQIRSQV ; MTHLRVIYER ; MNQSLSLLYN ; 600: VPAVAEEIQD ; EVDELLQKEQ ; NYSDDVLANM ; ISEPRISYGN ; DALMPSLTET ; 650: KTTVELLPVN ; GEFSLDDLQP ; WHPFGVDSVP ; ANTENEVEPV ; DARPAADRGL ; 700: TTRPGSGLTN ; IKTEEISEVK ; MDAEFGHDSG ; FEVRHQKLVF ; FAEDVGSNKG ; 750: AIIGLMVGGV ; VIATVIVITL ; VMLKKKQYTS ; IHHGVVEVDA ; AVTPEERHLS ; 770: KMQQNGYENP ; TYKFFEQMQN ;
Sequence Length	770
String	P12023
Sub Unit	Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, NUMB and DAB1. Binding to DAB1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1 (By similarity). In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1 (By similarity). Amyloid beta-42 binds CHRNA7 in hippocampal neurons (By similarity). Beta-amyloid associates with HADH2 (By similarity). Interacts with ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with CPEB1. Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Uniprot	P12023
Gene Name	App
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11820
Unigene	Mm.277585

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800183	E0946m	96T	$776		Add to Cart

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