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ELISA Kit for Mouse Aldehyde oxidase 1

SKU : BHE13800988

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5988m
Alternative Names	Azaheterocycle hydroxylase 1 ; 1.17.3.- ; Retinal oxidase ; Ao ; Ro
Categories	Elisa
Function	Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate.
Specificity	Natural and recombinant Mouse Aldehyde oxidase 1
Subcellular Location	Cytoplasm
Detection Range	0.312-20ng/mL
Entryname	AOXA_MOUSE
Method Type	Sandwich
Platform	PF01315
Protein Name	Aldehyde oxidase 1
Sensitivity	0.183ng/mL
Sequence	50: MDPIQLLFYV ; NGQKVVEKNV ; DPEMMLLPYL ; RKNLRLTGTK ; YGCGGGGCGA ; 100: CTVMISRYNP ; STKAIRHHPV ; NACLTPICSL ; HGTAVTTVEG ; LGNTRTRLHP ; 150: IQERIAKCHG ; TQCGFCTPGM ; VMSMYALLRN ; HPEPTLDQLT ; DALGGNLCRC ; 200: TGYRPIIDAC ; KTFCKASACC ; QSKENGVCCL ; DQEINGLAES ; QEEDKTSPEL ; 250: FSEEEFLPLD ; PTQELIFPPE ; LMRIAEKQPP ; KTRVFYGERV ; TWISPVTLKE ; 300: LVEAKFKYPQ ; APIVMGYTSV ; GPEVKFKGVF ; HPIIISPDRI ; EELGVISQAR ; 350: DGLTLGAGLS ; LDQVKDILAD ; IVQKLPEEKT ; QTYRALLKHL ; RTLAGSQIRN ; 400: MASLGGHIVS ; RHLDSDLNPL ; LAVGNCTLNL ; LSKDGERRIP ; LSEEFLRKCP ; 450: EADLKPQEVL ; VSVNIPWSRK ; WEFVSAFRQA ; QRQQNALAIV ; NSGMRVLFRE ; 500: GGGVIEELSI ; LYGGVGSTII ; SAKNSCQRLI ; GRPWNEGMLD ; TRCRLVLDEV ; 550: TLAASAPGGK ; VEFKRTLIIS ; FLFKFYLEVS ; QGLKREDPGH ; SPSLAGNHES ; 600: ALDDLHSKHP ; WRTLTHQNVD ; PAQLPQDPIG ; RPIMHLSGIK ; HATGEAIYCD ; 650: DMPAVDRELF ; LTFVTSSRAH ; AKIVSIDLSE ; ALSLPGVVDI ; ITADHLQEAN ; 700: TFGTETFLAT ; DEVHCVGHLV ; CAVIADSETR ; AKQAAKQVKV ; VYQDLAPLIL ; 750: TIEEAIQHKS ; FFKSERKLEC ; GNVDEAFKIV ; DQILEGEIHI ; GGQEHFYMET ; 800: QSMLVVPKGE ; DGEIDIYVST ; QFPKYIQDIV ; AATLKLSANK ; VMCHVRRVGG ; 850: AFGGKVGKTS ; ILAAITAFAA ; SKHGRAVRCI ; LERGEDMLIT ; GGRHPYLGKY ; 900: KAGFMNEGRI ; LALDVEHYCN ; GGCSLDESLW ; VIEMGLLKLD ; NAYKFPNLRC ; 950: RGWACRTNLP ; SNTALRGFGF ; PQAGLVTEAC ; ITEVAIKCGL ; SPEQVRTINM ; 1000: YKHVDTTHYK ; QEFSAKALSE ; CWRECMAKCS ; YFERKAAIGK ; FNAENSWKKR ; 1050: GMAVIPLKFP ; VGIGSVAMGQ ; AAALVHIYLD ; GSALVSHGGI ; EMGQGVHTKM ; 1100: IQVVSRELRM ; PMSSVHLRGT ; STETVPNTNA ; SGGSVVADLN ; GLAVKDACQT ; 1150: LLKRLEPIIS ; KNPQGTWKDW ; AQTAFDQSIS ; LSAVGYFRGY ; ESNIDWEKGE ; 1200: GHPFEYFVFG ; AACSEVEINC ; LTGDHKNIRT ; NIVMDVGHSI ; NPALDIGQVE ; 1250: GAFIQGMGLY ; TIEELSYSPQ ; GTLYSRGPNQ ; YKIPAICDIP ; TEMHISFLPP ; 1300: SEHSNTLYSS ; KGLGESGVFL ; GCSVFFAIHD ; AVKAARQERG ; ISGPWKLNSP ; 1333: LTPEKIRMAC ; EDKFTKMIPR ; DEPGSYVPCN ; IPV
Sequence Length	1333
Sub Unit	Homodimer.

Uniprot	O54754
Gene Name	Aox1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11761
Unigene	Mm.26787

Reference	1. "Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone." Kurosaki M., Demontis S., Barzago M.M., Garattini E., Terao M. Biochem. J.341:71-80(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY strain: CD-1. tissue: Liver. 2. "Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli." Huang D.-Y., Furukawa A., Ichikawa Y. Arch. Biochem. Biophys.364:264-272(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION AS RETINAL OXIDASE;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;HOMODIMER strain: C57BL/6 X CBA. tissue: Liver. 3. "The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region." Demontis S., Kurosaki M., Saccone S., Salvatore M., Garattini E., Terao M. Biochim. Biophys. Acta1489:207-222(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];DEVELOPMENTAL STAGE strain: 129/Sv. tissue: Thymus. 4. "Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons." Bendotti C., Prosperini E., Kurosaki M., Garattini E., Terao M. NeuroReport8:2343-2349(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 561-746;TISSUE SPECIFICITY strain: C57BL/6J. tissue: Liver. 5. "Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release." Weigert J., Neumeier M., Bauer S., Mages W., Schnitzbauer A.A., Obed A., Groeschl B., Hartmann A., Schaeffler A., Aslanidis C., Schoelmerich J., Buechler C. FEBS Lett.582:2965-2972(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ADIPOGENESIS;DEVELOPMENTAL STAGE;INDUCTION 6. "Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1." Schumann S., Terao M., Garattini E., Saggu M., Lendzian F., Hildebrandt P., Leimkuhler S. PLoS ONE4:E5348-E5348(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS OXIDASE;CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;HOMODIMER;KINETIC PARAMETERS;REACTION MECHANISM;ACTIVE SITE;MUTAGENESIS OF VAL-806; MET-884 AND GLU-1265 7. "Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression." Kurosaki M., Bolis M., Fratelli M., Barzago M.M., Pattini L., Perretta G., Terao M., Garattini E. Cell. Mol. Life Sci.70:1807-1830(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;IDENTIFICATION OF PARALOGS 8. "Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice." Swenson T.L., Casida J.E. Toxicol. Sci.133:22-28(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN XENOBIOTIC METABOLISM;TISSUE SPECIFICITY

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