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ELISA Kit for Mouse 2'-5'-oligoadenylate synthase 3

SKU : BHE13808484

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1715m
Alternative Names	2' ; 5'-oligoadenylate synthetase-like 10 ; oasl10
Categories	Elisa
Function	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Specificity	Natural and recombinant Mouse 2'-5'-oligoadenylate synthase 3
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.156-10ng/mL
Entryname	OAS3_MOUSE
Method Type	Sandwich
Platform	PF01909
Protein Name	2'-5'-oligoadenylate synthase 3
Sensitivity	0.087ng/mL
Sequence	50: MDLFHTPAGA ; LDKLVAHNLH ; PAPEFTAAVR ; GALGSLNITL ; QQHRARGSQR ; 100: PRVIRIAKGG ; AYARGTALRG ; GTDVELVIFL ; DCFQSFGDQK ; TCHSETLGAM ; 150: RMLLESWGGH ; PGPGLTFEFS ; QSKASRILQF ; RLASADGEHW ; IDVSLVPAFD ; 200: VLGQPRSGVK ; PTPNVYSSLL ; SSHCQAGEYS ; ACFTEPRKNF ; VNTRPAKLKN ; 250: LILLVKHWYH ; QVQTRAVRAT ; LPPSYALELL ; TIFAWEQGCG ; KDSFSLAQGL ; 300: RTVLALIQHS ; KYLCIFWTEN ; YGFEDPAVGE ; FLRRQLKRPR ; PVILDPADPT ; 350: WDVGNGTAWR ; WDVLAQEAES ; SFSQQCFKQA ; SGVLVQPWEG ; PGLPRAGILD ; 400: LGHPIYQGPN ; QALEDNKGHL ; AVQSKERSQK ; PSNSAPGFPE ; AATKIPAMPN ; 450: PSANKTRKIR ; KKAAHPKTVQ ; EAALDSISSH ; VRITQSTASS ; HMPPDRSSIS ; 500: TAGSRMSPDL ; SQIPSKDLDC ; FIQDHLRPSP ; QFQQQVKQAI ; DAILCCLREK ; 550: SVYKVLRVSK ; GGSFGRGTDL ; RGSCDVELVI ; FYKTLGDFKG ; QKPHQAEILR ; 600: DMQAQLRHWC ; QNPVPGLSLQ ; FIEQKPNALQ ; LQLASTDLSN ; RVDLSVLPAF ; 650: DAVGPLKSGT ; KPQPQVYSSL ; LSSGCQAGEH ; AACFAELRRN ; FINTCPPKLK ; 700: SLMLLVKHWY ; RQVVTRYKGG ; EAAGDAPPPA ; YALELLTIFA ; WEQGCGEQKF ; 750: SLAEGLRTIL ; RLIQQHQSLC ; IYWTVNYSVQ ; DPAIRAHLLC ; QLRKARPLVL ; 800: DPADPTWNVG ; QGDWKLLAQE ; AAALGSQVCL ; QSGDGTLVPP ; WDVTPALLHQ ; 850: TLAEDLDKFI ; SEFLQPNRHF ; LTQVKRAVDT ; ICSFLKENCF ; RNSTIKVLKV ; 900: VKGGSSAKGT ; ALQGRSDADL ; VVFLSCFRQF ; SEQGSHRAEI ; ISEIQAHLEA ; 950: CQQMHSFDVK ; FEVSKRKNPR ; VLSFTLTSQT ; LLDQSVDFDV ; LPAFDALGQL ; 1000: RSGSRPDPRV ; YTDLIHSCSN ; AGEFSTCFTE ; LQRDFITSRP ; TKLKSLIRLV ; 1050: KYWYQQCNKT ; IKGKGSLPPQ ; HGLELLTVYA ; WEQGGQNPQF ; NMAEGFRTVL ; 1100: ELIVQYRQLC ; VYWTINYSAE ; DKTIGDFLKM ; QLRKPRPVIL ; DPADPTGNLG ; 1138: HNARWDLLAK ; EATVYASALC ; CVDRDGNPIK ; PWPVKAAV
Sequence Length	1138
Sub Unit	Monomer.

Uniprot	Q8VI93
Gene Name	Oas3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:246727
Unigene	Mm.204887

Reference	1. "Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family." Kakuta S., Shibata S., Iwakura Y. J. Interferon Cytokine Res.22:981-993(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY strain: C57BL/6J. tissue: Colon. 2. "Positional cloning of the murine flavivirus resistance gene." Perelygin A.A., Scherbik S.V., Zhulin I.B., Stockman B.M., Li Y., Brinton M.A. Proc. Natl. Acad. Sci. U.S.A.99:9322-9327(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C3H/RV. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. 6. "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla." Perelygin A.A., Zharkikh A.A., Scherbik S.V., Brinton M.A. J. Mol. Evol.63:562-576(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW 7. "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities." Kristiansen H., Gad H.H., Eskildsen-Larsen S., Despres P., Hartmann R. J. Interferon Cytokine Res.31:41-47(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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