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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

SKU : BHE13808709

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0269m
Alternative Names	Phosphoinositide phospholipase C-gamma-1 ; Phospholipase C-gamma-1 ; PLC-gamma-1 ; Plcg-1
Categories	Elisa
Function	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as fibroblast growth factor receptors. Plays a role in actin reorganization and cell migration.
Specificity	Natural and recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Subcellular Location	Cell projection lamellipodium Cell projection ruffle Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Detection Range	0.156-10ng/ml
Entryname	PLCG1_MOUSE
Method Type	Sandwich
Platform	PF00168
Protein Name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Sensitivity	0.084ng/mL
Sequence	50: MAGVATPCAN ; GCGPGAPSEA ; EVLHLCRSLE ; VGTVMTLFYS ; KKSQRPERKT ; 100: FQVKLETRQI ; TWSRGADKIE ; GSIDIREIKE ; IRPGKTSRDF ; DRYQEDPAFR ; 150: PDQSHCFVIL ; YGMEFRLKTL ; SLQATSEDEV ; NMWIKGLTWL ; MEDTLQAATP ; 200: LQIERWLRKQ ; FYSVDRNRED ; RISAKDLKNM ; LSQVNYRVPN ; MRFLRERLTD ; 250: LEQRSGDITY ; GQFAQLYRSL ; MYSAQKTMDL ; PFLETNALRT ; GERPEHCQVS ; 300: LSEFQQFLLE ; YQGELWAVDR ; LQVQEFMLSF ; LRDPLREIEE ; PYFFLDELVT ; 350: FLFSKENSVW ; NSQLDAVCPD ; TMNNPLSHYW ; ISSSHNTYLT ; GDQFSSESSL ; 400: EAYARCLRMG ; CRCIELDCWD ; GPDGMPVIYH ; GHTLTTKIKF ; SDVLHTIKEH ; 450: AFVASEYPVI ; LSIEDHCSIA ; QQRNMAQHFR ; KVLGDTLLTK ; PVDIAADGLP ; 500: SPNQLRRKIL ; IKHKKLAEGS ; AYEEVPTSVM ; YSENDISNSI ; KNGILYLEDP ; 550: VNHEWYPHYF ; VLTSSKIYYS ; EETSSDQGNE ; DEEEPKEASS ; STELHSSEKW ; 600: FHGKLGAGRD ; GRHIAERLLT ; EYCIETGAPD ; GSFLVRESET ; FVGDYTLSFW ; 650: RNGKVQHCRI ; HSRQDAGTPK ; FFLTDNLVFD ; SLYDLITHYQ ; QVPLRCNEFE ; 700: MRLSEPVPQT ; NAHESKEWYH ; ASLTRAQAEH ; MLMRVPRDGA ; FLVRKRNEPN ; 750: SYAISFRAEG ; KIKHCRVQQE ; GQTVMLGNSE ; FDSLVDLISY ; YEKHPLYRKM ; 800: KLRYPINEEA ; LEKIGTAEPD ; YGALYEGRNP ; GFYVEANPMP ; TFKCAVKALF ; 850: DYKAQREDEL ; TFTKSAIIQN ; VEKQDGGWWR ; GDYGGKKQLW ; FPSNYVEEMI ; 900: NPAVLEPERE ; HLDENSPLGD ; LLRGVLDVPA ; CQIAIRPEGK ; NNRLFVFSIS ; 950: MPSVAQWSLD ; VAADSQEELQ ; DWVKKIREVA ; QTADARLTEG ; KMMERRKKIA ; 1000: LELSELVVYC ; RPVPFDEEKI ; GTERACYRDM ; SSFPETKAEK ; YVNKAKGKKF ; 1050: LQYNRLQLSR ; IYPKGQRLDS ; SNYDPLPMWI ; CGSQLVALNF ; QTPDKPMQMN ; 1100: QALFMAGGHC ; GYVLQPSTMR ; DEAFDPFDKS ; SLRGLEPCVI ; CIEVLGARHL ; 1150: PKNGRGIVCP ; FVEIEVAGAE ; YDSTKQKTEF ; VVDNGLNPVW ; PAKPFHFQIS ; 1200: NPEFAFLRFV ; VYEEDMFSDQ ; NFLAQATFPV ; KGLKTGYRAV ; PLKNNYSEDL ; 1250: ELASLLIKID ; IFPAKENGDL ; SPFSGISLRE ; RASDASSQLF ; HVRAREGSFE ; 1300: ARYQQPFEDF ; RISQEHLADH ; FDSRERSTSD ; GPSSATNLIE ; DPLHDKLWKC ; 1302: SL
Sequence Length	1302
String	Q62077
Sub Unit	Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with RALGPS1. Interacts (via SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with RET (By similarity). Interacts with AGAP2 via its SH3 domain. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK. Interacts with KIT. Interacts with AXL.

Uniprot	Q62077
Gene Name	Plcg1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18803
Unigene	Mm.44463

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808709	E0269m	96T	$776		Add to Cart

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