CCN family member 4 ; Wnt-1-induced secreted protein ; CCN4
Categories
Elisa
Function
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
Specificity
Natural and recombinant Human WNT1-inducible-signaling pathway protein 1