Transmembrane protein 49 ; TDC1 ; TMEM49 ; HSPC292
Categories
Elisa
Function
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
Specificity
Natural and recombinant Human Vacuole membrane protein 1
Subcellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Vacuole membrane Multi-pass membrane protein Endoplasmic reticulum