UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
Specificity
Natural and recombinant Human UDP-glucuronosyltransferase 1-4
Subcellular Location
Microsome Endoplasmic reticulum membrane Single-pass membrane protein