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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Tyrosine-protein kinase receptor UFO

SKU : BHE13811210

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2483h
Alternative Names	AXL oncogene ; UFO
Categories	Elisa
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitement of GRB2 and phosphatidylinositol-3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
Specificity	Natural and recombinant Human Tyrosine-protein kinase receptor UFO
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	62.5-4000pg/mL
Entryname	UFO_HUMAN
Method Type	Sandwich
Platform	PF00041
Protein Name	Tyrosine-protein kinase receptor UFO
Sensitivity	31.31pg/mL
Sequence	50: MAWRCPRMGR ; VPLAWCLALC ; GWACMAPRGT ; QAEESPFVGN ; PGNITGARGL ; 100: TGTLRCQLQV ; QGEPPEVHWL ; RDGQILELAD ; STQTQVPLGE ; DEQDDWIVVS ; 150: QLRITSLQLS ; DTGQYQCLVF ; LGHQTFVSQP ; GYVGLEGLPY ; FLEEPEDRTV ; 200: AANTPFNLSC ; QAQGPPEPVD ; LLWLQDAVPL ; ATAPGHGPQR ; SLHVPGLNKT ; 250: SSFSCEAHNA ; KGVTTSRTAT ; ITVLPQQPRN ; LHLVSRQPTE ; LEVAWTPGLS ; 300: GIYPLTHCTL ; QAVLSNDGMG ; IQAGEPDPPE ; EPLTSQASVP ; PHQLRLGSLH ; 350: PHTPYHIRVA ; CTSSQGPSSW ; THWLPVETPE ; GVPLGPPENI ; SATRNGSQAF ; 400: VHWQEPRAPL ; QGTLLGYRLA ; YQGQDTPEVL ; MDIGLRQEVT ; LELQGDGSVS ; 450: NLTVCVAAYT ; AAGDGPWSLP ; VPLEAWRPGQ ; AQPVHQLVKE ; PSTPAFSWPW ; 500: WYVLLGAVVA ; AACVLILALF ; LVHRRKKETR ; YGEVFEPTVE ; RGELVVRYRV ; 550: RKSYSRRTTE ; ATLNSLGISE ; ELKEKLRDVM ; VDRHKVALGK ; TLGEGEFGAV ; 600: MEGQLNQDDS ; ILKVAVKTMK ; IAICTRSELE ; DFLSEAVCMK ; EFDHPNVMRL ; 650: IGVCFQGSER ; ESFPAPVVIL ; PFMKHGDLHS ; FLLYSRLGDQ ; PVYLPTQMLV ; 700: KFMADIASGM ; EYLSTKRFIH ; RDLAARNCML ; NENMSVCVAD ; FGLSKKIYNG ; 750: DYYRQGRIAK ; MPVKWIAIES ; LADRVYTSKS ; DVWSFGVTMW ; EIATRGQTPY ; 800: PGVENSEIYD ; YLRQGNRLKQ ; PADCLDGLYA ; LMSRCWELNP ; QDRPSFTELR ; 850: EDLENTLKAL ; PPAQEPDEIL ; YVNMDEGGGY ; PEPPGAAGGA ; DPPTQPDPKD ; 894: SCSCLTAAEV ; HPAGRYVLCP ; STTPSPAQPA ; DRGSPAAPGQ ; EDGA
Sequence Length	894
String	P30530
Sub Unit	Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1.

Uniprot	P30530
Gene Name	AXL
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:558
Unigene	Hs.590970

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811210	E2483h	96T	$536		Add to Cart

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