JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Tyrosine-protein kinase JAK3

SKU : BHE13805918

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0425h
Alternative Names	Janus kinase 3 ; JAK-3 ; Leukocyte janus kinase ; L-JAK
Categories	Elisa
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Specificity	Natural and recombinant Human Tyrosine-protein kinase JAK3
Subcellular Location	Endomembrane system Peripheral membrane protein Cytoplasm
Detection Range	78-5000pg/mL
Entryname	JAK3_HUMAN
Method Type	Sandwich
Platform	PF07714
Protein Name	Tyrosine-protein kinase JAK3
Sensitivity	36pg/mL
Sequence	50: MAPPSEETPL ; IPQRSCSLLS ; TEAGALHVLL ; PARGPGPPQR ; LSFSFGDHLA ; 100: EDLCVQAAKA ; SGILPVYHSL ; FALATEDLSC ; WFPPSHIFSV ; EDASTQVLLY ; 150: RIRFYFPNWF ; GLEKCHRFGL ; RKDLASAILD ; LPVLEHLFAQ ; HRSDLVSGRL ; 200: PVGLSLKEQG ; ECLSLAVLDL ; ARMAREQAQR ; PGELLKTVSY ; KACLPPSLRD ; 250: LIQGLSFVTR ; RRIRRTVRRA ; LRRVAACQAD ; RHSLMAKYIM ; DLERLDPAGA ; 300: AETFHVGLPG ; ALGGHDGLGL ; LRVAGDGGIA ; WTQGEQEVLQ ; PFCDFPEIVD ; 350: ISIKQAPRVG ; PAGEHRLVTV ; TRTDNQILEA ; EFPGLPEALS ; FVALVDGYFR ; 400: LTTDSQHFFC ; KEVAPPRLLE ; EVAEQCHGPI ; TLDFAINKLK ; TGGSRPGSYV ; 450: LRRSPQDFDS ; FLLTVCVQNP ; LGPDYKGCLI ; RRSPTGTFLL ; VGLSRPHSSL ; 500: RELLATCWDG ; GLHVDGVAVT ; LTSCCIPRPK ; EKSNLIVVQR ; GHSPPTSSLV ; 550: QPQSQYQLSQ ; MTFHKIPADS ; LEWHENLGHG ; SFTKIYRGCR ; HEVVDGEARK ; 600: TEVLLKVMDA ; KHKNCMESFL ; EAASLMSQVS ; YRHLVLLHGV ; CMAGDSTMVQ ; 650: EFVHLGAIDM ; YLRKRGHLVP ; ASWKLQVVKQ ; LAYALNYLED ; KGLPHGNVSA ; 700: RKVLLAREGA ; DGSPPFIKLS ; DPGVSPAVLS ; LEMLTDRIPW ; VAPECLREAQ ; 750: TLSLEADKWG ; FGATVWEVFS ; GVTMPISALD ; PAKKLQFYED ; RQQLPAPKWT ; 800: ELALLIQQCM ; AYEPVQRPSF ; RAVIRDLNSL ; ISSDYELLSD ; PTPGALAPRD ; 850: GLWNGAQLYA ; CQDPTIFEER ; HLKYISQLGK ; GNFGSVELCR ; YDPLGDNTGA ; 900: LVAVKQLQHS ; GPDQQRDFQR ; EIQILKALHS ; DFIVKYRGVS ; YGPGRQSLRL ; 950: VMEYLPSGCL ; RDFLQRHRAR ; LDASRLLLYS ; SQICKGMEYL ; GSRRCVHRDL ; 1000: AARNILVESE ; AHVKIADFGL ; AKLLPLDKDY ; YVVREPGQSP ; IFWYAPESLS ; 1050: DNIFSRQSDV ; WSFGVVLYEL ; FTYCDKSCSP ; SAEFLRMMGC ; ERDVPALCRL ; 1100: LELLEEGQRL ; PAPPACPAEV ; HELMKLCWAP ; SPQDRPSFSA ; LGPQLDMLWS ; 1124: GSRGCETHAF ; TAHPEGKHHS ; LSFS
Sequence Length	1124
String	P52333
Sub Unit	Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.

Uniprot	P52333
Gene Name	JAK3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3718
Unigene	Hs.515247

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13805918	E0425h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.